Amino Acid + Dextrose + Eloctrolytes

IndIcated as a source of amIno acIds, glucose and electrolytes In adult and pedIatrIc patIents needIng IV nutrItIon. ThIs Is partIcularly suItable for patIents wIth basal amIno acId requIrements

Parenteral Nutritional preparations

This is sterile, hypertonic and non-pyrogenic solution of amino acids, electrolytes & dextrose. When amino acid injections are administered with an appropriate caloric source (e.g., dextrose, fructose, sorbitol), nitrogen balance is improved. Maximal nitrogen utilization is promoted by providing adequate calories to meet metabolic needs, usually at least 168 kJ/kg/day (40 kcal/kg/day).

Adults: The nitrogen requirement for maintenance of body protein mass depends on the condition of the patient (nutritional state and degree of metabolic stress). The requirements are 0.1-0.15 g nitrogen/kg body weight/day (no or minor metabolic stress and normal nutritional state), 0.15-0.2 g nitrogen/kg body weight/day (moderate metabolic stress with or without malnutrition) and up to 0.2-0.25 g nitrogen/kg body weight/day (severe catabolism as in burns, sepsis and trauma). The dosage range 0.1-0.25 g nitrogen/kg body weight/day corresponds to 11-27 mL Amino Acid IV Infusion with 10% Glucose and Electrolytes /kg body weight/day, respectively. Obese patient: In obese patients, the dose should be based on the estimated ideal weight. Depending upon patient requirements, up to 1000-2000 mL of Amino Acid IV Infusion with 10% Glucose and Electrolytes may be infused IV per 24 hrs. Amino Acid IV Infusion with 10% Glucose and Electrolytes should be infused slowly, at a rate not exceeding 1000 mL in 6 hrs corresponding to approximately 2.8 mL/min. In patients with basal amino acids requirements, the less concentrated Amino Acid IV Infusion with 10% Glucose and Electrolytes may be used. Infants and Children: In children and infants, a maximal rate of infusion of 30 mL Amino Acid IV Infusion with 10% Glucose and Electrolytes/kg body weight/day is recommended, with a stepwise increase in the rate of administration during the 1st week of treatment.

At the recommended dosage the amino acid have no pharmacological effects and is not expected to interact with other medicaments.

Patients with inborn errors of amino acid metabolism, severe liverdysfunction and in severe uremia when dialysis facilities are not available. Due to the content of glucose,this drug is contraindicated in patients with hyperosmolar nonketotic diabetic coma

Nausea ,Hypersensitivity reactions, thrombophlebitis

No specific studies have been performed to assess the safety of Amino Acids + Electrolytes + Glucose in pregnancy and lactation.

Store below 30°C temperature. Protect from sunlight. Avoid freezing. Keep out of reach of children. The prepared amino acids/dextrose admixture should be administered immediately. If not, it should be stored under refrigeration (2-8°C) and used within 24 hours. Do not remove the unit from overwrap until ready for use. The overwrap is an oxygen and U.V. barrier. The inner bag maintains the sterility of the product.

Each 100 ml contains- Essential Amino Acids: L-lsoleucine USP 0.600 g L-Leucine USP 0.730 g L-Lysine (as Hydrochloride) USP 0.580 g L-Methionine USP 0.400 g L-Phenylalanine USP 0.560 g L-Threonine USP 0.420 g L-Tryptophan USP 0.180 g L-Valine USP 0.580 g L-Histidine USP 0.480 g Non-Essential Amino Acids: L-Arginine USP 1.150 g L-Alanine USP 2.070 g L-Tyrosine USP 0.040 g Glycine ( Aminoacetic Acid ) USP 1.030 g L-Proline USP 0.680 g L-Serine USP 0.500 g Electrolytes: Sodium ( Na+) 70.0 Potassium ( K+ ) 60.0 Acetate ( CH3COO- ) 150.0 Magnesium (Mg2+) 10.0 Chloride (Cl-) 70.0 Phosphate ( as HP04 2- ) 60.0 Carbohydrate: AAnhydrous Glucose (Dextrose) BP 20.00 g