Docusate is indicated in Constipation, Bowel evacuation, Softening of ear wax, Constipation.
Docusate sodium works by allowing more water to be absorbed by the stool. Docusate does not stay in the gastrointestinal tract, but is absorbed into the bloodstream and excreted via the gallbladder after undergoing extensive metabolism. The effect of docusate may not necessarily be all due to its surfactant properties. Perfusion studies suggest that docusate inhibits fluid absorption or stimulates secretion in the portion of the small intestine known as the jejunum.
Constipation: Adult: 50-300 mg daily in divided doses. Max: 500 mg daily. Child: ?12 yr Same as adult dose. Bowel evacuation: Adult: As adjunct to abdominal radiological procedures: 400 mg given with barium meal. Child: ?12 yr Same as adult dose.
Docusate Sodium softgel capsules should not be taken concurrently with mineral oil.
Presence of abdominal pain, nausea, vomiting, intestinal obstruction. Perforation of ear drum or ear inflammation (otic). Rectal admin in patient with haemorrhoids or anal fissures. Children. Pregnancy and lactation.
Anorectal pain or bleeding (rectal). Rarely, diarrhoea, abdominal cramps, nausea, skin rash.
Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
In rare cases of overdose, excessive loss of water and electrolytes should be treated by encouraging the patient to drink plenty of fluid. Electrolyte loss should be replenished where appropriate.
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
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