It is a photosensitizer indicated for the treatment of patients with predominantly classic subfoveal choroidal neovascularization due to age-related macular degeneration, pathologic myopia or presumed ocular histoplasmosis
Drugs for Age-Related Macular Degeneration (AMD)
Reconstitute each vial of this with 7 mL of Sterile Water for it must be protected from light and used within 4 hours. ? The recommended light dose is 50 J/cm2 of neovascular lesion administered at an intensity of 600 mW/cm2. The wavelength of the laser light should be 689 nm. This light dose is administered over 83 seconds, starting 15 minutes after the start of this infusion
(verteporfin for injection) is contraindicated for patients with porphyria or a known hypersensitivity to any component of this preparation.
injection site reactions ? visual disturbances
Pregnancy Category- C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risksLactation Verteporfin and its diacid metabolite have been found in human breast milk following an intravenous infusion at the recommended human dose of 6 mg/m2. Verteporfin was present in breast milk at levels up to 66% of the corresponding plasma levels and declined below the limit of quantification (2 ng/mL) within 24 hours. The diacid metabolite had lower peak concentrations but persisted up to at least 48 hours. Because of the potential for serious adverse reactions in nursing infants from it, a decision should be made whether to discontinue nursing or postpone treatment, taking into account the importance of the drug to the mother
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