Angiotensin II Receptor antagonist;
Candesartan Cilexetil is an ester prodrug that is hydrolysed in the body to the active form Candesartan during absorption from the gastro-intestinal tract. Candesartan is angiotensin II receptor (type AT1) antagonist. Candesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues (eg, vascular smooth muscle, adrenal gland).
2-32 mg once or twice daily.
No significant drug interactions have been reported in studies of Candesartan Cilexetil given with other drugs such as glyburide, nifedipine, digoxin, warfarin, hydrochlorothiazide and oral contraceptives in healthy volunteers. Because candesartan is not metabolised by the cytochrome P-450 system and has no effects on P-450 enzymes, interactions with drugs that inhibit, or are metabolised by, those enzymes could not be expected.
Hypersensitivity. Pregnancy (2nd & 3rd trimester) & lactation.Volume or Na depletion, preexisting renal insufficiency; aortic or mitral valve stenosis, hypertrophic obstructive cardiomyopathy, renal artery stenosis, primary hyperaldosteronism. Patients w/ a history of angioedema, urticaria. Monitor serum K levels esp in elderly & renally impaired patients. Hypotension may occur during major surgery & anesth due to suppression of the reninangiotensin system.
Dizziness, headache, vertigo, depression, somnolence, fever, back pain, upper resp tract infections, 1st dose orthostatic hypotension, rash, diarrhoea, decreased haemoglobin, renal impairment, hepatitis.
This drug should not be used during pregnancy unless there are no alternatives and the benefit outweighs the risk to the fetus.Use is not recommended and a decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.
Store in a cool & dry place. Protect from light and moisture
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