Ricketsial infection, Mycoplasma pneumonia infections, Chlamydial Infections, Nongonococcal or non specific urethritis, Lyme disease, Brucellosis, Miscellaneous infections including granuloma inguinale, cholera, glanders, relapsing fever & V. vulnifians, urinary tract infections, bronchitis, PID, STD, travelers diarrhoea, acne vulgaris, prostatitis, syphilis, anaerobic infections.
Tetracycline is a broad-spectrum antibiotic which is bacteriostatic for manybacteria, rickettsiae, chlamydia, mycoplasma and brucella. It exerts its antimicrobial effect by inhibiting protein synthesis. After a single oral dose of Tetracycline peak plasma concentration is attained in 2 to 4 hours. The drug's half-life is in the range of 6 to 9 hours. Because of its enterohepatic circulation, Tetracycline may be present in the blood for a long time after cessation of therapy.
1-2 g daily given in 2-4 divided doses, children : 25-50 mg/kg daily.
Tetracycline in combination with methoxy-fluorane may result nephrotoxicity. Antacids containing calcium, aluminium or magnesium impair the absorption of tetracycline and result in decreased serum level. Tetracycline inhibits the antimicrobial activity of penicillin when used concomitantly.
Hypersensitivity, systemic lupus erythematosus, renal impairment, in impaired liver function high doses should be avoided. Potentiality hepatotoxic drugs (including erythromycin, chloramphenicol, isoniazide & sulphonamides) should not be given concomitantly.
Depression of bone growth, discoloration of the teeth when given during tooth development (i.e. during the later half of pregnancy, during infancy & in childhood) anaphylaxis, urticaria & rashes are uncommon. Photosensitivity reactions, epigastric distress & nausea . Vomiting can occur, appears to aggravate preexisting renal failure, candidiasis, Esophageal ulcerations.
Tetracycline should not be used during pregnancy, lactation & in children.
Store in a cool and dry place. Protect from light. Keep out of reach of children.
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