Acne vulgaris, Gluten enteropathy or sprue, Gnathostomiasis, Gonorrhoea, Superficial ophthalmic infections, Susceptible infections
Eye Anti-Infectives & Antiseptics, Tetracycline Group of drugs
Oxytetracycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane.
Intramuscular: Susceptible infections: Adult: 250 mg once daily or 300 mg daily in 2-3 divided doses. Child: >8 yr: 15-25 mg/kg (max 250 mg) daily in 2-3 divided doses. Oral: Susceptible infections: Adult: 250-500 mg 4 times daily. Max 4 g daily. Child: >8 yr: 25-50 mg/kg daily in 4 divided doses. Acne: Adult: 250-500 mg bid. Unco-mplicated gonorrhoea: Adult: 1.5 g initially, followed by 0.5 g four times daily up to a total of 9 g Take 1 hr before or 2 hr after meals.
Antacids containing Aluminium, Calcium, Magnesium, Zinc or Iron salts may impair the absorption of Oxytetracycline. In long term therapy, Tetracyclines depress plasma prothrombin activity and reduced doses of concomitant anticoagulants may be necessary. A few cases of pregnancy or breakthrough bleeding have been attributed to the concurrent use of Tetracyclines or Oxytetracyclines with oral contraceptives.
Hypersensitivity to tetracyclines, children <8 yr, renal damage. Pregnancy, lactation.
Anorexia, nausea, vomiting,diarrhoea, glossitis, dysphagia, photosensitivity, oesphageal irritation and ulceration, nephrotoxicity, enterocolitis, rash (rare), blood dyscrasias. Headache, visual disturbances; intracranial hypertension; bulging fontanelles
Pregnancy Category D. There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
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