Pneumonia, Uncomplicated Urinary Tract Infections, Complicated Urinary Tract Infections, Pyelonephritis, Uncomplicated Skin Infections, Skin Structure Infections, Complicated Intra-Abdominal Infections
4th Generation Cephalosporin; Antimicrobial
Cephalosporins are bactericidal and have the same mode of action as other beta-lactam antibiotics (such as penicillins). Cephalosporins disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by transpeptidases known as penicillin binding proteins (PBPs).
Cefepime should be administered intravenously over approximately 30 minutes. Before administration ensure that the powder has been fully dissolved in the solution.
Renal function should be monitored carefully if high doses of aminoglycosides are to be administered with Cefepime because of the increased potential of nephrotoxicity and ototoxicity of aminoglycoside antibiotics. Nephrotoxicity has been reported following concomitant administration of other cephalosporins with potent diuretics such as furosemide.
Cefepime is contraindicated in patients who have shown immediate hypersensitivity reactions to Cefepime or the cephalosporin class of antibiotics, penicillins or other beta-lactam antibiotics.
As with some other drugs in this class, encephalopathy (disturbance of consciousness including confusion, hallucinations, stupor & coma), myoclonus & seizures have beenreported.
Pregnancy Category B. Nursing Mothers Cefepime is excreted in human breast milk in very low concentrations (0.5 ug/mL). Caution should be exercised when Cefepime is administered to a nursing woman.
Patients who receive an overdose should be carefully observed and given supportive treatment. In the presence of renal insufficiency, hemodialysis, not peritoneal dialysis, is recommended to aid the removal of cefepime from the body. Accidental overdosing has occurred when large doses were given to patients with impaired renal function. Symptoms of overdose include encephalopathy (disturbance of consciousness including confusion, hallucinations, stupor, and coma), myoclonus, seizures, and neuromuscular excitability.
Do not use later than the date of expiry. Keep all medicines out of the reach of children. To be dispensed only on the prescription of a registered physician.
.png&w=384&q=75)