Heart failure, Hypertension. Lisinopril tablets are indicated for the treatment of hypertension in adult patients and pediatric patients 6 years of age and older to lower blood pressure.
Lisinopril competitively inhibits ACE from converting angiotensin I to angiotensin II (a potent vasoconstrictor) resulting in increased plasma renin activity and reduced aldosterone (a hormone that causes water and Na retention) secretion. This promotes vasodilation and BP reduction.
Adult: Initially, 5-10 mg daily given at bedtime to avoid precipitous fall in BP. Patient w/ renovascular hypertension, vol depletion, severe hypertension: Initially, 2.5-5 mg once daily. Patient on diuretic: Initially, 5 mg once daily. Maintenance: 20 mg once daily, up to 80 mg daily may be used if needed. Child: 6 yr: Initially, 0.07 mg/kg (up to 5 mg once daily). Adjust dose until desired BP goal is achieved.
May enhance hypotensive effect with diuretics. May increase risk of renal function deterioration and decrease antihypertensive effect with NSAIDs. May increase serum levels and toxicity of lithium. Increased risk of hyperkalaemia with K-sparing diuretics and K supplements. May increase nitritoid reactions of gold Na thiomalate.
History of angioedema related to previous treatment w/ ACE inhibitors, hereditary or idiopathic angioedema. Bilateral renal artery stenosis. Pregnancy (2nd or 3rd trimester), lactation. Hypovolaemia, hyperkalaemia, collagen vascular disease, valvular stenosis; before, during or immediately after anaesthesia, preexisting renal insufficiency, unilateral renal artery stenosis. Children <6 yr. Assess renal function. May impair ability to drive or operate machinery.
upper reap tract infection; rash; diarrhoea, nausea, vomiting, abdominal pain; chest pain, weakness; orthoststic effects; hypotension; hyperkalaemia; impotence; decreased haemoglobin; increased serum creatinine. Severe hypotension, angioedema.
Pregnancy & lactation is contraindicated.
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
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