Antithrombotic action, mediated through inhibition of platelet activation, secondary prophylaxis following myocardial infarction & unstable angina or cerebral transient ischemic attacks.
Platelet Aggregation Inhibitor;
By decreasing platelet aggregation, Aspirin inhibits thrombus formation on the arterial side of the circulation, where thrombi are formed by platelet aggregation and anticoagulants have little effect. Aspirin is the analgesic of choice for headache, transient musculoskeletal pain and dysmenorrhoea. It has anti-inflammatory and antipyretic properties, which may be useful. Enteric-coated Aspirin reduces intestinal disturbance and gastrointestinal ulceration due to aspirin.
150 mg at diagnosis & 75 mg daily thereafter.
Salicylates may enhance the effect of anticoagulants, oral hypoglycaemic agents, phenytoin and sodium valporate. They inhibit the uricosuric effect of probenecid and may increase the toxicity of sulphonamides. They may also precipitate bronchospasm or induce attacks of asthma in susceptible subjects.
Hypersensitivity to aspirin, hypoprothrombinaemia, haemophilia & peptic ulceration, asthma.
Hypersensitivity, asthma, urate kidney stones, chronic gastro-intestinal blood loss, tinnitus, nausea & vomiting.
Aspirin should be avoided during the last 3 months of pregnancy. It should not be used by patients who are breast feeding.
Overdosage produces dizziness, tinnitus, sweating, nausea and vomiting, confusion and hyperventilation. Gross overdosage may lead to CNS depression with coma, cardiovascular collapse and respiratory depression. If the overdosage is suspected, the patient should be kept under observation for at least 24 hours, as symptoms and salicylate blood levels may not become apparent for several hours. Treatment of overdosage consists of gastric lavage and forced alkaline diuresis. Haemodialysis may be necessary in severe cases.
Keep all medicines out of reach of children. Store in a cool and dry place, protected from light.
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