Therapy and prophylaxis of volume deficiency (hypovolaemia) and shock (volume replacement therapy) in connection with surgery (haemorrhagic shock). Injuries (traumatic shock),infections (septic shock),bums (bum shock). Savings of donor blood during surgery e,g acute normovolaemic haemodilution. Therapeutic dilution of blood (haemodilution)
Adult: Dose Up to 50 mL of (hydroxyethyl starch in sodium chloride injection) per kg of body weight per day (equivalent to 3 g hydroxyethyl starch and 7.7 mEq sodium per kg of body weight). This dose is equivalent to 3500 mL of (hydroxyethyl starch in sodium chloride injection) for a 70 kg patient. Pediatric Dose: Dosage in children should be adapted to the individual patient colloid needs,taking into account the disease state,as well as the hemodynamic and hydration status Newborns and infants: 2-12 years: Mean dose of 36 mL/kg IV Give initial 10-20 mL by slow IV infusion and monitor for anaphylactoid reaction
Hypersensitivity to hydroxyethyl starch fluid overload (hyperhydration) and especially in cases of pulmonary edema and congestive heart failure renal failure with oliguria or anuria not related to hypovolemia patients receiving dialysis treatment severe hypernatremia or severe hyperchloremia intracranial bleeding.
Anaphylactoid reactions (hypersensitivity,mild influenzalike symptoms,bradycardia,tachycardia,bronchospasm,non-cardiac pulmonary edema). In the event of an intolerance reaction,the infusion should be discontinued immediately and the appropriate emergency medical treatment initiated. Skin and subcutaneous tissue disorders (Common,> 1 to < 10%,dose dependent): Prolonged administration of high dosages of hydroxyethyl starch may cause pruritus (itching) which is an undesirable effect observed with all hydroxyethyl starches
Use in pregnancy: Animal reproduction studies have not been conducted with Hydroxyethyl Starch in Sodium Chloride infusion and it is also not known whether it can cause fetal harm or affect reproductive capacity when administered during pregnancy. This infusion should be given during pregnancy only if clearly needed Use during lactation: It is not known whether Hydroxyethyl starch is excreted in human milk. Because many drugs are excreted in human milk,caution should be exercised when Hydroxyethyl Starch in Sodium Chloride infusion is administered to a nursing woman.
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