Short-term management of moderate to severe acute post-operative pain & acute pain of other origins.
Pyrrotizine Carboxylic Acid; Nonsteroidal anti-inflammatory drug
Ketorolac Tromethamine is a potent analgesic of the non-steroidal anti-inflammatory drugs (NSAIDs). It acts by inhibiting the cyclooxygenase enzyme system and hence inhibits the prostaglandin synthesis. It demonstrates a minimal anti-inflammatory effect at its analgesic dose.
Injecetion: For adults (65 years): Initial dose is 60 mg IM (Single). Maintenance dose is 30 mg IM/IV 6 hourly. Maximum dose is 120 mg/day. For elderly patients (>65 years), Initial dose is 30 mg IM. Maintenance dose is 10-15 mg IM/ IV 6 hourly. Maximum dose is 60 mg/day. The maximum duration of treatment should not exceed two days. Tablets: 10 mg every 6 hours as required up to 7 days.
Other NSAIDs or aspirin: Increase the side effects of ketorolac Tromethamine.
Anti-coagulants: Enhance anti-coagulant effect.
Beta Blocker: Reduce the anti-hypertensive effect .
ACE Inhibitors: Increase the risk of renal impairment.
Methotrexate: Enhance the toxicity of methotrexate.
Patients having hypersensitivity to this drug or other NSAIDs & those patients in whom aspirin or other prostaglandin synthesis inhibitors induce allergic reactions. It is also contraindicated in a history of peptic ulcer or gastro-intestinal bleeding, moderate or severe renal impairment in a history of asthma. Ketorolac tromethamine can cause gastro-ntestinal irritation, ulcers or bleeding in patients with or without a history of previous symptoms. Since ketorolac tromethamine & its metabolites are excreted primarily by the kidney, patients with moderate to severe impairment of renal function (serum creatinine greater than 160 micromol/l) should not receive.
Nausea, vomiting, gastrointestinal bleeding, melaena, peptic ulcer, pancreatitis, anxiety, drowsiness, dizziness, headache, hallucinations, excessive thirst, inability to concentrate, insomnia, malaise, fatigue, pruritus, urticaria, skin photosensitivity, Lyell’s syndrome, Stevens-Johnson syndrome, flushing, bradycardia, hypertension, palpitations, chest pain, infertility in female, dyspnoea, asthma, pulmonary oedema, fever, injection site pain.
Contraindicated during pregnancy, labour or delivery, or in mothers who are breast feeding.
Keep in a dry place away from light and heat. Keep out of the reach of children.
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