Amoebiasis (Intestinal & hepatic), Giardiasis, Trichomoniasis, Bacterial vaginosis, Treatment of susceptible anaerobic infections.
5-Nitroimidazole antiprotozoal/antibiotic; Antibacterial
Ornidazole is a 5-nitroimidazole derivative active against protozoa and anaerobic bacteria. It is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms.
Amoebiasis : Adults: 500 mg twice a day for 5 days. Children: 10-25 mg/kg body weight in 2 divided doses. Amoebic dysentery : Adults : 1.5 gm once a day for 3 days. Children: 40 mg/kg body weight once a day for 3 days. Giardiasis: Adults : 1.5 gm once daily for 1-2 days. Children: 40 mg/kg body weight for 2 days. Trichomoniasis : 1.5 gm once or 500 mg twice a day for 5 days. Sexual partner should also be treated at the same time. Bacterial vaginosis : 3 tablets of 500 mg each as a single dose or one tablet of 500 mg once daily for 5-7 days.
Like other imidazoles, Ornidazole has a mild potential to cause disulfiramlike reactions. Concomitant administration of oral anticoagulants may increase the risk of haemorrhage due to diminished hepatic metabolism. Ornidazole has been reported to decrease the clearance of 5-fluorouracil.
Hypersensitivity, epilepsy, peripheral neuropathy. In patient with ataxia, vertigo, & mental confusion, Ornidazole should be prescribed with caution.
Nausea, vomiting, epigastric pain, dizziness, headache, lassitude. Unlike other nitroimidazoles, Ornidazole does not interact with alcohol, Leukopenia has been described occasionally.
Ornidazole should be prescribed only if the potential benefit justifies the potential risk to foetus/neonate.
Store at room temperature and protect from light and moisture.
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