Fosfomycin trometamol is indicated only for the treatment of acute uncomplicated lower urinary tract infections (acute cystitis) in females above 12 years of age caused by the following susceptible pathogens: Enterobacteriaceae (including Escherichia coli), Enterococcus faecalis. Fosfomycin trometamol is not indicated for the treatment of pyelonephritis or perinephric abscess or where resistance is likely (previous treatment failure, infection due to non-susceptible organism).
broad spectrum antibiotic
Fosfomycin has in vitro activity against a broad range of gram-positive and gram-negative aerobic microorganisms, associated with uncomplicated urinary tract infections. Fosfomycin Trometamol is a phosphonic acid derivative. It is a synthetic, broad spectrum, bactericidal antibiotic for oral administration. The bactericidal action of Fosfomycin is due to its inactivation of the enzyme enolpyruvyl transferase, thereby irreversibly blocking the condensation of uridine diphosphate N-acetylglucosamine with p-enolpyruvate, one of the first steps in bacterial cell wall synthesis.
The recommended dosage for women 18 years of age and older for acutecystitis is one sachet of Fosfomycin with or without food. This medicine should not be used in children
When Fosfomycin is coadministered with metoclopramide, which increases gastrointestinal motility, lowers the serum concentration and urinary excretion of fosfomycin. Other drugs that increase gastrointestinal motility may produce similar effects.
Hypersensitivity to fosfomycin trometamol or to any of the excipients. Patients with severe renal insufficiency (creatinine clearance < 10 ml/min). Patients undergoing haemofiltration, haemodialysis or peritoneal dialysis.
Diarrhoea, Vaginitis, Nausea, Headache
This drug should not be used during pregnancy unless the benefit outweighs the risk.A decision should be made to discontinue breastfeeding or to notadminister the drug, taking into account the importance of the drug to the mother.
When Fosfomycin is coadministered with metoclopramide, which increases gastrointestinal motility, lowers the serum concentration and urinary excretion of fosfomycin. Other drugs that increase gastrointestinal motility may produce similar effects.
Keep out of reach of children. Store in a dry place, below 25°C temperature and protected from light.
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