Permethrin cream contains Permethrin, a pyrethroid, which is a topical scabicidal agent for the treatment of infestation with Sarcoptes Scabiei (scabies). It acts on the nerve cell membrane to disrupt the sodium channel current by which the polarization of the membrane is regulated. Delayed repolarization & paralysis of the pests are the consequences of this disturbance.
Pharmacokinetics: The only approved route of administration is the topical route and there are few human data available on systemic exposure or kinetics following permethrin application to the skin. Some presystemic metabolism occurs in skin. Less than 0.5% of applied permethrin is absorbed during the first 48 hours. Absorbed permethrin is rapidly metabolized by ester hydrolysis, most likely in the liver and the products are excreted primarily in the urine.
Adults: two full tube (15 gm) or one full tube (30 gm), Children: 1/4 (15 gm) to 1/8 (30 gm) of a tube. How to use: Patients >2 months of age can use the dermal cream. It should be applied to the whole body excluding head.
The treatment of eczemodous like reactions with corticosteroids should be withheld prior to treatment with permethrin, as there is a risk of exacerbating the scabies infestation by reducing the immune response to the mite.
Hypersensitivity. The treatment of eczematous-like reactions with corticosteroids should be withheld prior to treatment with Permethrin.
Skin discomfort, burning, stinging or tingling erythema, edema, eczema, rash & pruritus.
Permethrin is suggested not to use during pregnancy & lactation
Store in a cool, dry place, away from light & keep out of the reach of children.
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