NEOCAL D

This preparation is indicated for- Prevention and treatment of osteoporosis; To maintain strong bone growth and teeth; For proper functioning heart, muscle and nerves; As nutritional supplement; For bone development and constant regeneration of bone; Pregnancy & lactation; Deficiency state of calcium, vitamin D, magnesium, zinc, copper, manganese & boron.

Specific mineral & vitamin combined preparations

Nutrition is the most important to prevent osteoporosis and other bone related diseases. Calcium, Magnesium & Vitamin D3 are the macronutrients for bone. Without Vitamin D3 very little Calcium is absorbed. Like Calcium, Magnesium increases bone strength and rigidity. Recent epidemiological studies showed that some micronutrients like Copper, Manganese, Zinc & Boron play an important role in bone health. Deficiency of the micronutrients is noticed in patients with osteoporosis.

Adults, Elderly and children above 12 years of age: 2 tablets per day, preferably one tablet each morning and evening. Children below 12 years of age: Not recommended.

The risk of hypercalcemia should be considered in patients taking thiazide diuretics since these drugs can reduce urinary calcium excretion. Hypocalcaemia must be avoided in digitalized patients. Certain foods (e.g. those containing oxalic acid, phosphate or phytinic acid) may reduce the absorption of calcium. Concomitant treatment with phenytoin or barbiturates can decrease the effect of Vitamin-D 3 because of metabolic activation. Concomitant use of glucocorticoids can decrease the effect of Vitamin D3. The effects of digitalis and other cardiac glycosides may be attenuated with the oral administration of calcium combined with Vitamin-D 3 . Strict medical supervision is needed and, if necessary monitoring of ECG and calcium. Calcium salts may reduce the absorption of thyroxin, bisphosphonates, sodium fluoride, quinolone or tetracycline antibiotics or iron. It is advisable to allow a minimum period of four hours before taking the calcium.

Hypercalcemia and hyperparathyroidism, Hypercalciuria and nephrolithiasis, Hypersensitivity to the component of this preparation, Severe renal insufciency, Concomitant digoxin therapy. Patients with mild to moderate renal failure or mild hypercalciuria should be supervised carefully. Periodic checks of plasma calcium levels and urinary calcium excretion should be made in patients with mild to moderate renal failure or mild hypercalciuria.

Orally administered calcium carbonate may be irritating to the GI tract. It may also cause constipation. Hypercalcemia is rarely produced by administration of calcium alone, but may occur when large doses are given to patients with chronic renal failure. Also there may be allergic reactions, irregular heartbeats, nausea, vomiting, decreased appetite dry mouth and drowsiness. Following administration of vitamin-D supplements occasionally skin rash has been reported. Side effects from micro nutrients are rare.

Usually should be used considering the risk benefit ratio.

Symptoms of overdosage may include nausea and vomiting, severe drowsiness, dry mouth, loss of appetite, metallic taste, stomach cramps, diarrhea, headache & constipation.

Keep in a dry place away from light and heat. Keep out of the reach of children.

Each film-coated tablet contains- Calcium Carbonate BP equivalent to 600 mg elemental Calcium Vitamin D3 BP (as Cholecalciferol) 200 IU Magnesium Oxide BP equivalent to 40 mg Magnesium Manganese Sulfate Monohydrate BP equivalent to 1.8 mg Manganese Cupric Oxide equivalent to 1 mg Copper Boron Citrate equivalent to 250 mcg Boron Zinc Oxide BP equivalent to 7.5 mg Zinc Each effervescent tablet contains- Calcium Carbonate BP equivalent to 600 mg elemental Calcium Vitamin D3 BP (as Cholecalciferol) 400 IU Magnesium Oxide BP equivalent to 40 mg Magnesium Manganese Sulfate Monohydrate BP equivalent to 1.8 mg Manganese Cupric Oxide equivalent to 1 mg Copper Boron Citrate equivalent to 250 mcg Boron Zinc Oxide BP equivalent to 7.5 mg Zinc