Indicated for the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis.
Polyene antifungal; Ocular anti-infective agent
Natamycin is a tetraene polyene antibiotic derived from Streptomyces natalensis. Natamycin probably exerts its antifungal effects by binding to sterols in the fungal cell membrane to produce a change in membrane permeability that allows loss of essential cellular constituents. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, Natamycin is predominantly fungicidal. Topical administration appears to produce effective concentration of Natamycin within the corneal stroma but not in intraocular fluid.
OPHTHALMIC Blepharitis, conjunctivitis & keratitis: Adult: Ophthamic susp 5%: Instil 1 drop in conjunctival sac every 1-2 hr; reduce to 1 drop 6-8 times a day after 3-4 days. Duration of treatment: 2-3 wk. Ointment 1%: Apply bid-tid.
May increase spread of fungal eye infection when used with topical corticosteroid.
Hypersensitivity. Pregnancy & lactation. Porphyria.
GI disturbances (oral). Irritation (local). Conjunctival chemosis & hyperaemia (ophthalmic).
It is also not known whether natamycin can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. It is not known if natamycin is excreted in human milk; however, systemic absorption is not expected following topical ophthalmic administration.
Store in a cool and dry place. Protect from light. Do not freeze. Do not use for longer than one month after first opening of the bottle.
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