Infections of the ear, nose & throat, genitourinary tract, skin & skin structure, lower respiratory tract; gonorrhea, acute uncomplicated (ano-genital & urethral infections). H. pylori eradication to reduce the risk of duodenal ulcer recurrence in combination with clarithromycin plus lansoprazol as triple therapy. Prophylactic cover for patients at risk of developing endocarditis when undergoing dental surgery.
Aminopenicillin; Antimicrobial
Amoxicillin is a broad spectrum penicillin. It is effective against a wide range of Gram-positive and Gram-negative bacteria. It acts through the inhibition of biosynthesis of cell wall. Amoxicillin is stable in the presence of gastric acid and is rapidly absorbed after oral administration. After an oral dose, peak plasma concentration of Amoxicillin is reached within 1 to 2 hours. Amoxicillin is widely distributed at varying concentration in body tissues and fluids.
Adult : Mild/Moderate-500 mg every 12 hours or 250 mg every 8 hours, Severe-875 mg every 12 hours or 500 mg every 8 hours. Children: Mild/Moderate-25 mg/kg/day in divided doses every 12 hours or 20mg/kg/ day in divided doses every 8 hours, Severe-45 mg/kg/day in divided doses every 12 hours or 40 mg/kg/day in divided doses every 8 hours. Gonorrhea, Acute uncomplicated ano-genital, & urethral infections in male & female 3 g as single oral dose. Prepubertal children 50 mg/ kg Amoxicillin, combined with 25 mg/kg Probenecid as a single dose
Concurrent use of Amoxicillin and Probenecid may result in increased and prolonged blood levels of Amoxicillin. Amoxicillin may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.
It is contraindicated for patients hypersensitive to Penicillin. In renal impairment the excretion of antibiotic will be delayed & depending on the degree of impairment it may be necessary to reduce the total daily dose. Caution should also be exercised in case of erythematous rashes, glandular fever, history of allergy etc.
Hyperactivity, agitation, insomnia, dizziness; maculopapular rash, exfoliative dermatitis, urticaria, hypersensitivity vasculitis; diarrhoea, nausea, vomiting; anaemia, thrombocytopenia, leucopenia, agranulocytosis. Neuromuscular hypersensitivity; pseudomembranous colitis.
Can be used safely throughout pregnancy at the normal adult dose. Can be used safely during lactation in most instances.
Keep in a dry place away from light and heat. Keep out of the reach of children.
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