Urinary fibrinolysis, usualIy a normal physiological phenomenon, may contribute to excessive urinary tract fibrinolytic bleeding associated with surgical hematuria (following prostatectomy and nephrectomy) or nonsurgical hematuria (accompanying polycystic or neoplastic diseases of the genitourinary system).
Fibrinotytic Inhibitor; HaemostaticlAntihaemorrhagic
The fibrinolysis-inhibitory effects of Aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
Treatment & prophylaxis of haemorrhage: Adult: Initially, 4-5 g, followed by 1-1.25 g every hr for about 8 hr or until bleeding has been controlled. Max: 24 g in 24 hr. Patients w/ haemophilia undergoing dental extraction: Adult: Initially, 6 g immediately after the procedure, followed by 6g every 6 hr for up to 10 days. INTRAVENOUS Treatment & prophylaxis of haemorrhage: Adult: Initially, 4-5 g as a 2% soln over 1 hr followed by a 1 g/hr infusion continued for up to 8 hr or until bleeding has been controlled. Max: 24 g in 24 hr.
Bleeding due to disseminated intravascular coagulation. Rapid IV administration. Renal or cardiac disorders. Urinary tract bleeding, haematuria of upper urinary tract origin; venoo cclusive hepatic disease, skeletal myopathy, neonates. Monitor creatinine phosphokinase. Avoid admin w/ factor IX complex concentrates. Pregnancy & lactation.
Oedema, headache, malaise, allergic & anaphylactic reactions, anaphylaxis, bradycardia, hypotension, peripheral ischaemia, thrombosis, abdominal pain, diarrhoea, nausea, vomiting, agranulocyiosis, coagulation disorder, leukopaenia, thrombocytopaenia, increased CPK, muscle damage, myalgia, myopathy, myositis, rhabdomyolysis, confusion, convulsions, delirium, dizziness, hallucinations, intracranial hypertension, stroke, syncope, dyspnoea, nasal congestion, pulmonary embolism, pruritus, rash, tinnitus, decreased vision, watery eyes, increased BUN, dry ejaculation. Cardiac & hepatic damage.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.
Store in a cool, dry place, protected from light. Store the suspension below 30° C. Keep out of reach of children.
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