Inflamed dermatoses such as intertrigo & infected eczema, primary irritant or contact allergic eczema or seborrheic eczema including that associated with acne. perianal & genital dermatitis.
Miconazole is a substituted imidazole, is one of the family of azoles useful in treating the superficial candidiasis and of the skin infections dermatophytosis and pityriasis versicolor, acanthameaba, seborrhoic dermatitis. Also active against Aspergillus spp., Cryptococcus neoformans, Pseudalescheria boydii and some gram-positive bacteria including Staphylococci and Streptococci.
Hydrocortisone is a naturally occurring glucocorticoid that's now prepared synthetically. Its important function is in the skin injury such as inflammation. Also it has antipruritic, antimycotic and vasoconstrictive activity.
Miconazole is imidazole antifungal agents that interfere with ergosterol synthesis and therefore alters the permeability of the cell membrane of sensitive fungi. Thus causes the killing of fungi, when applied to the skin, Hydrocortisone is absorbed into the skin cells. It prevents the release of certain chemicals, which is responsible for inflammation. Thus hydrocortisone reduces inflammation.
Two or three times daily.
Amphotericin antagonizes the activity of Miconazole.
Hypersensitivity. It should be used with caution when applied to extensive surface areas or under occlusive dressings including baby napkins. Amphotericin antagonises effect of Miconazole.
Local sensitivity may occur. Corticosteroids can be absorbed sufficient amount to produce systemic Effects.
Topical steroids should not be extensively used in pregnancy.
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
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