It is indicated for active immunization to prevent invasive meningococcal disease caused by Neisseria meningitidis serogroups A, C, Y and W-135. Menactra is approved for use in individuals 9 months through 55 years of age. Menactra does not prevent N meningitidis serogroup B disease
Vaccines, Anti-sera & Immunoglobulin
Meningococcal Polysaccharide Vaccine is a freeze-dried preparation of the group-specific polysaccharide antigens from Neisseria meningitidis Group A, Group C, Group Y and Group W135. When reconstituted, the vaccine is a clear, colorless sterile solution for subcutaneous use.
A 0.5 mL dose for intramuscular injection. Primary Vaccination: ? Children 9 through 23 months of age: Two doses, three months apart. ? Individuals 2 through 55 years of age: A single dose. Booster Vaccination: ? A single booster dose may be given to individuals 15 through 55 years of age at continued risk for meningococcal disease, if at least 4 years have elapsed since the prior dose.
Severe allergic reaction (eg, anaphylaxis) after a previous dose of a meningococcal capsular polysaccharide-, diphtheria toxoid- or CRM197- containing vaccine, or to any component of it.
Injection site tenderness, erythema, and swelling; irritability, abnormal crying, drowsiness, appetite loss, vomiting, and fever. Common (?10%) solicited side effects in individuals 2 through 55 years of age who received a single dose were injection site pain, redness, induration, and swelling; anorexia and diarrhea. Other common solicited adverse events were irritability and drowsiness (2-10 years of age), headache, fatigue, malaise, and arthralgia
Safety and effectiveness of Menactra have not been established in children younger than 9 months of age, pregnant women, nursing mothers, and adults older than 55 years of age
Store in a refrigerator (2-8°C). Do not freeze. Store in the original package in order to protect from light.
After reconstitution, 1 dose (0.5 ml) contains:
Neisseria meningitidis group A polysaccharide: 5 micrograms
Neisseria meningitidis group C polysaccharide: 5 micrograms
Neisseria meningitidis group W-135 polysaccharide: 5 micrograms
Neisseria meningitidis group Y polysaccharide: 5 micrograms
Conjugated to tetanus toxoid carrier protein: 44 micrograms
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