Vitamin B12 is the common name for a nutrient known scientifically as methylcobalamin. It's used as a dietary supplement and to treat certain anemias. Vitamin B12 plays an important role in helping the body make red blood cells.
Mecobalamin is one of the two coenzyme forms of vitamin B12. It differs from cyanocobalamin in that the cyano group at the cobalt is replaced with a methyl group. It is a cofactor in the enzyme methionine synthase which functions to transfer methyl groups for the regeneration of methionine from homocysteine. It is required for integrity of myelin, neuronal function, proper red blood cell formation and DNA synthesis. Mecobalamin helps in the synthesis of neuronal lipids, regeneration of axonal nerves, promotes axonal transport and has neuroprotective activity.
ORAL Peripheral neuropathies: Adult: 1500 mcg/day in 3 divided doses. PAR ENTERAL Peripheral neuropathies: Adult: 500 mcg daily IM/IV 3 times/wk. Megaloblastic anaemia caused by vit B12 deficiency: Adult: 500 mcg daily IM/IV 3 times/wk. Maintenance dose: After about 2 mth of therapy, reduce dose to single admin of 500 mcg every 1-3 mth.
Absorption of vitamin B12 from the gastrointestinal tract may be reduced by neomycin, aminosalicylic acid, histamine H2-antagonists, omeprazole, and colchicine. Serum concentrations may be decreased by use of oral contraceptives. Many of these interactions are unlikely to be of clinical significance but should be taken into account when performing assays for blood concentrations.
Are allergic to vitamin B12 or any other ingredients found in the drug Have a genetic condition called optic atrophy where the nerve that connects the eye to the brain wastes away Have blood in your urine Have an ongoing infection Have low iron or folate levels Have a bone disease called polycythemia
Oral: Anorexia, nausea, vomiting & diarrhoea. Parenteral: Rash, headache, hot sensation, diaphoresis & pain/ induration at IM inj site. Anaphylactoid reactions (parenteral).
Depending on its form and the dose, vitamin B12 has two different safety profiles for pregnant women. Vitamin B12 tablets that you swallow or let melt under your tongue are considered safe during pregnancy. It's not clear, however, whether high-dose vitamin B12 could harm your unborn baby. In either case, you should tell your doctor if you are pregnant or plan to become pregnant before taking this medication. You should also tell your doctor if you are breastfeeding or plan to breastfeed. Vitamin B12 is found in breast milk and is therefore not recommended for mothers who are breastfeeding.
Store at room temperature. Protect from moisture and light.
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