Treatment of hypertension or congestive heart failure in patients who develop hypokalemia when thiazide or other kaliuretic diuretics are used alone, or in patients in whom maintenance of normal serum potassium levels is clinically important (eg, digitalized patients); alone or as adjunctive treatment with other antihypertensive agents.
Thiazide diuretics & related drugs
Adult: 1-2 tablets (5 mg amiloride & 50 mg hydrochlorothiazide) daily in single or divided doses, increasing if necessary to maximum 4 tablets. Children: Safety and efficacy not established.
Hyperkalemia (serum potassium levels greater than 5.5 mEq/L); concurrently with other potassium-sparing diuretics (eg, spironolactone), potassium supplements (including potassium-rich diet) except in severe or refractory cases of hypokalemia; impaired renal function; sensitivity to any components of product.
Cardiovascular: Arrhythmia, tachycardia, palpitations (amiloride). CNS: Headache, fatigue, tiredness, weakness, dizziness, encephalopathy, tremors, decreased libido (amiloride); restlessness (hydrochlorothiazide). Dermatologic: Mild skin rash, pruritus, alopecia (amiloride); urticaria, purpura (hydrochlorothiazide). EENT (eye, ear, nose, and throat): Increased ocular pressure, tinnitus (amiloride); transient blurred vision, xanthopsia (hydrochlorothiazide). GI: Nausea, anorexia, GI and abdominal pain, flatulence, activation of peptic ulcer, dyspepsia, heartburn, dry mouth (amiloride); pancreatitis, cramping, GI irritation, sialadenitis (hydrochlorothiazide). Genitourinary: Bladder spasm, polyuria, urinary frequency (amiloride); interstitial nephritis (hydrochlorothiazide). Hematologic: Aplastic anemia, neutropenia (amiloride); agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia (hydrochlorothiazide). Hepatic: Jaundice. Metabolic: Hyperkalemia, hyperglycemia, glucosuria, hyperuricemia (hydrochlorothiazide). Respiratory: Shortness of breath, cough (amiloride); respiratory distress, including pneumonitis and pulmonary edema (hydrochlorothiazide).
Pregnancy Category B Lactation: Amiloride: undetermined hydrochlorothiazide: excreted in breast milk.
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