Acute exacerbations of chronic bronchitis, Community-acquired pneumonia.
Fluoroquinolone; Antibiotic
Gemifloxacin is a fluoroquinolone antibiotic. It is bactericidal with minimum bactericidal concentrations. Gemifloxacin acts by inhibiting DNA synthesis through inhibition of the bacterial type II topoisomerases, DNA gyrase, and/or topoisomerase IV (TOPO IV) which are both essential for bacterial growth.
Gemifloxacin is rapidly absorbed after oral administration. It is widely distributed throughout the body. Studies in healthy subjects showed that gemifloxacin is distributed rapidly into target tissues and body fluids such as the lung (epithelial lining fluid, alveolar macrophages, bronchial tissue) and nasal secretions.
Following oral administration of gemifloxacin, approximately 36% and 61% of the dose is excreted in the urine and feces, respectively, as unchanged drug and metabolites. AUC values were generally only slightly higher (approx. 10%) in women than in men. No dose adjustment is required based on gender
In Acute Exacerbations of Chronic Bronchitis (AECB) once daily for 5 days. For Community- Acquired Pneumonia (CAP) in mild to moderate severity once daily for 5 days & in severe cases once daily for 7 days.
Gemifloxacin absorption is significantly reduced when aluminium or magnesium containing antacids and iron salts are concomitantly administered. Gemifloxacin should be taken at least 2 hours before or 3 hours after these agents. Gemifloxacin should be taken at least 2 hours before sucralfate administration. No clinically significant interactions have been observed when Gemifloxacin was co-administered with omeprazole theophylline, digoxin, warfarin and oral contraceptives.
Known hypersensitivity to Gemifloxacin & other quinolones, Patients who have previously suffered tendon damage with fluoroquinolones. Adequate hydration of patients receiving Gemifloxacin should be maintained to preventthe formation of a highly concentrated urine & crystalluria. Side Effect: Generally well tolerated. The most side Effects include abdominal pain, diarrhea, headache, nausea, rash & vomiting.
Diarrhoea, nausea, vomiting; headache, dizziness; rash. urticana. May cause elevation of liver enzymes.
Gemifloxacin should not be used in pregnant or lactating women. The safety & efficacy of Gemifloxacin in pregnant or lactating women have not been established.
No specific antidote is known. Dialysis does not remove Gemifloxacin sufficiently to be useful in overdose. In the event of acute oral overdosage, the stomach should be emptied by inducing vomiting or by gastric lavage; the patient should be carefully observed, treated symptomatically and adequate hydration should be maintained.
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
.png&w=384&q=75)