Oropharyngeal & Esophageal Candidiasis.
Nystatin is an antifungal antibiotic. Which has fungistatic or fungicidal activity against variety of pathogenic and nonpathogenic yeast and fungi, including Candida albicans. Nystatin exerts its antifungal activity by binding to sterols in the fungal cell membrane. As a result of binding, the membrane is no longer able to function as a selective barrier, and potassium and other cellular constituents are lost. It is poorly absorbed from the gastrointestinal tract.
Children: In intestinal & oral candidiasis (thrush) 1,00,000 units (1 ml) should be dropped into the mouth four times daily. The longer the suspension is kept in contact with the affected area in the mouth, before swallowing, the greater will be its effect. For prophylaxis in the newborn the suggested dose is 1,00,000 units (1 ml) once daily or as prescribed by the physician. Adult: For the treatment of intestinal or esophageal candidiasis 5,00,000 units (5 ml) by mouth 3 or 4 times daily. The dose may be doubled, if required. For prophylaxis of intestinal candidiasis in adults 10,00,000 units (10 ml) daily. For prophylaxis to suppress the over growth of Candida albicans in patients receiving broad spectrum antibiotic therapy 10,00,000 units (10 ml) daily. For the treatment of dental sores & oral infection 1,00,000 units (1 ml) suspension should be dropped into the mouth four times daily. Older people with intestinal candidiasis who are unable to swallow tablets should be given 5,00,000 units (5 ml) suspension four times daily.
Oral irritation or sensitization, nausea, diarrhoea, gastrointestinal distress, nausea & vomiting. Rash, including urticaria has been reported rarely.
Nystatin should be prescribed during pregnancy only if the potential benefits to be derived outweigh the possible risks involved; caution should be exercised when Nystatin is prescribed for nursing woman.
Store in a cool and dry place, protect from light. Keep out of reach of children.
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