Adapalene acts on retinoid receptors that are commonly found in the skin of face,
back and chest. Biochemical and pharmacological studies have demonstrated that
Adapalene is a modulator of cellular differentiation, keratinization, and
inflammatory processes, all of that represent important features in the pathology of
acne vulgaris. Adapalene binds with specific retinoic acid nuclear receptors that
normalize the differentiation of follicular epithelial cells resulting in decreased
microcomedone formation. Absorption of Adapalene through human skin is low.
Cream: Once daily at night-time. Gel: Once daily in the evening.
Concomitant use of other potentially irritating topical products (medicated or
abrasive soaps and cleansers, soaps and cosmetics that have a strong drying
effect, products with high concentrations of alcohol, astringents, spices or lime)
should be approached with caution Exercise particular caution in using
preparations containing sulfur, resorcinol or salicylic acid in combination with
Adapalene If any of these preparations have been used, it is advisable not to
start therapy with Adapalene until the effects of such preparations in skin
have subsided. If combined use of both medications is important, it is better to
use in two different times.
Hypersensitivity to Adapalene. Adapalene should not be applied to cuts, abrasions, eczematous or sunburned skin. Concomitant use of other potentially irritating topical products (medicated or abrasive soaps & cleaners, soaps & cosmetics that have a strong drying effect, products with high concentrations of alcohol, astringents, spices or lime) should be approached with caution. Exercise particular caution in using preparations containing sulfur, resorcinol or salicylic acid in combination with Adapalene.
Erythema, scaling, dryness, pruritus, burning sensation, skin irritation, stinging sunburn, acne flares.
Use Adapalene during pregnancy only if the potential benefit justifies the
potential risk to the fetus. It is not known whether this drug is excreted in breast
milk. Exercise caution when administering Adapalene to a nursing mother.
Store below 25° C. and in a dry place. Do not freeze.
Each gram cream contains Adapalene BP 1 mg. Each gm gel contains Adapalene BP 3 mg.
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