Sertaconazole is an imidazole derivative and a preparation that destroys fungi. The preparation is used to treat vaginal candidiasis caused by fungi in the Candida family.
Other Antifungal preparations
Sertaconazole is a highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethylation via the inhibition of the enzyme cytochrome P450 14α-demethylase. This enzyme converts lanosterol to ergosterol, and is required in fungal cell wall synthesis.
One vaginal suppository in the evening, to be inserted deeply into the vagina, preferably while lying down. If symptoms persist, repeat with a second vaginal suppository 7 days after the first administration.
The concomitant use with contraceptive diaphragm may cause the sheath or diaphragm to break during the insertion of the vaginal suppository (See Contraindications). The concomitant use with local spermicidal contraception is not recommended as the spermicide may be inactivated.
Contraindications
Known hypersensitivity to any imidazole antimycotic or to any of the excipients. Concomitant use of contraceptive diaphragm. Precautions & Warnings
Upon confirmation of diagnosis, etiological factors causing the infection should be investigated, and patients should be counseled so as to avoid future recurrence.
Use soaps which are of neutral or alkaline pH when washing the outer genitals, as lower pH favours candidiasis.
Practice good personal hygiene; wear preferably cotton underclothes; avoid vaginal douches.
If mycosis occurs on the vulvar or perianal areas, apply an antifungal cream on these areas.
Consider the treatment of sexual partner wherever applicable for each specific case.
Do not interrupt treatment during menstruation.
Concomitant treatment for any bacterial infection associated with candidiasis is advisable.
In case of local intolerance or allergic reaction, stop treatment.
With the absence of systemic absorption of sertaconazole after the application of a vaginal suppository, side effects are unlikely to occur. However, there may be the rare occasions of allergic reactions and the manifestation of local intolerance such as a feeling of burning sensation or exacerbation of pruritus which generally disappears on discontinuation of treatment.
If you are pregnant or breast-feeding, think you may be pregnant or intend to become pregnant, ask your doctor or pharmacist for advice before taking this medicine. Preclinical studies have shown that sertaconazole does not have any teratogenic or embryotoxic effects. The safety of the use of the drug in pregnant women has not been studied. That is why the preparation is administered only when the expected benefit for the mother exceeds any potential risk for the fetus. The safety of using the drug during breastfeeding has not been studied. The preparation is administered only if the expected benefit for the mother exceeds any potential risk for the infant. Before taking any medicine, consult your doctor if you are pregnant or breastfeeding.
Keep this medicine out of the sight and reach of children. Store at temperatures below 30°C.
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