indicated in the treatment of allergic disorders, such as bronchial asthma.
Sympathornimetic Agent; Vasoconstrictor
Ephedrine is a stimulant drug, belonging to a group of medicines known as sympathomimetics. Specifically it is both an alpha and beta adrenergic agonist. In addition, Ephedrine enhances the release of norepinephrine, a strong endogenous alpha agonist. The action of this compound is notably similar to that of the body's primary adrenergic hormone epinephrine (adrenaline), which also exhibits action toward both alpha and beta receptors. When administered, Ephedrine will notably increase the activity of the central nervous system, as well as have a stimulatory effect on other target cells.
ORAL Diabetic neuropathic oedema: Adult: 30-60 mg tid. INTRAVENOUS Reversal of spinal or epidural anaesthesia-induced hypotension: Adult: 3-6 mg or up to9 mg in a 3 mg/mL soln given as slow lnj repeated every 3-4 min, as needed. Max Dose: 30mg.
Administration of Ephedrine may cause a hypertensive crisis in patients receiving an Monoamine Oxidase Inhibitor (including an Reversible Inhibitor of Monoamine Oxidase type A). Ephedrine should be avoided or used with care in patients undergoing anaesthesia with cyclopropane, halothane, or other volatile anaesthetics. An increased risk of arrhythmias may occur if given to patients receiving cardiac glycosides, quinidine, or tricyclic antidepressants, and there is an increased risk of vasoconstrictor or pressor effects in patients receiving ergot alkaloids or oxytocin
Hypersensitivity. Hypertension, thyrotoxicosis, BPH. Lactation. Lschaemic heart disease, hypert hyroidism, diabetes mellitus, hypertension, angle-closure glaucoma, renal impairment; prostatic enlargement; pregnancy, elderly.
Anxiety, tachycardia, tremor, dry mouth, hypertension, cardiac arrhythmias, impaired circulation to the extremities, nervousness, insomnia, palpitations. Difficulty in micturition in patients w/ prostatic enlargement. Nasal drops: Local irritation, rebound nasal congestion & drug-induced rhinitis on prolonged use. Delusions, hallucinations. Seen w/ hypersensitivity & overdosage. Acute CNS & CVS stimulation presenting as vomiting, fever, hypertension, psychosis. Cardiac arrhythmias.
may use during pregnancy; risk of fetal harm not expected based on limited human data. Use during breastfeeding is not recommended.
When given in sufficiently large doses Ephedrine gives rise in most patients to certain minor reactions, such as giddiness, headache, nausea, vomiting, sweating, palpitations, difficulty in micturition, tremors, anxiety, restlessness and insomnia; some patients may exhibit these symptoms even with the usual therapeutic dosage.
Store in a cool, dry place, protected from light. Keep all medicines out of reach of children.
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