Etodolac is indicated for acute or long-term use in Rheumatoid Arthritis & Osteoarthritis.
Acetic acid derivative & related substances; Anti-inflammatory & antirheumatic products, NSAID
Similar to other NSAIDs, the anti-inflammatory effects of etodolac result from inhibition of the enzyme cycooxygenase (COX). This decreases the synthesis of peripheral prostaglandins involved in mediating inflammation. Etodolac binds to the upper portion of the COX enzyme active site and prevents its substrate, arachidonic acid, from entering the active site. Etodolac was previously thought to be a non-selective COX inhibitor, but it is now known to be 5-50 times more selective for COX-2 than COX-1. Antipyresis may occur by central action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat loss.
Adults: One tablet daily, The safety of doses in excess of 600 mg per day has not been established. Elderly: No change in initial dosage is generally required in the elderly. Children: Not recommended.
Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors. This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE-inhibitors. When Etodolac is administered with Aspirin, its protein binding is reduced, although the clearance of free Etodolac is not altered. The clinical significance of this interaction is not known; however, as with other NSAIDs, concomitant administration of Etodolac and Aspirin is not generally recommended because of the potential of increased adverse effects.
Etodolac should not be used in patients who have previously shown hypersensitivity to it. Etodolac should not be used in patients with active peptic ulceration or a history of peptic ulcer disease. Due to possible cross-reactivity, Etodolac should not be administered to patients who experience asthma, rhinitis or urticaria during therapy with aspirin or other nonsteroidal anti-inflammatory drugs. Etodolac should be used with caution in patients with fluid retention, hypertension or heart failure.
Reported side Effects include nausea, epigastric pain, diarrhoea, indigestion, heartburn, flatulence, abdominal pain, constipation, vomiting, ulcerative stomatitis dyspepsia, gastritis, haematemesis, melaena, rectal bleeding, colitis, vasculitis, headaches, dizziness, abnormal vision, pyrexia, drowsiness, tinnitus, rash, pruritus, fatigue, depression, insomnia, confusion, paraesthesia, tremor, weakness/malaise, dyspnoea, oedema, palpitations, bilirubinuria, hepatic function abnormalities & jaundice, urinary frequency, dysuria, angioedema, anaphylactoid reaction, photosensitivity, urticaria & Stevens-Johnson syndrome.
Safety in human pregnancy has not been established & Etodolac should not be used during pregnancy. Safety of Etodolac use during lactation has not been established & as such its use in nursing mothers should be avoided.
Symptoms following acute NSAID overdose are usually limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain which are generally reversible with supportive care.
Do not store above 30°C. Keep away from light and out of the reach of children.
.png&w=384&q=75)