Respiratory tract infections, genito-urinary tract infections, skin infections, acute & chronic osteomyelitis, acute brucellosis, septicaemia, nocardiosis & other infections caused by susceptible organisms.
Cotrimoxazole having broad spectrum bactericidal activity against a wide range of gram-positive & gram-negative bacteria and some protozoa. Co-trimoxazole containing Trimethoprim and Sulphamethoxazole in a 1:5 combination exerts its bactericidal action by the sequential blockade of two bacterial enzyme systems in the biosynthesis of folinic acid in the microorganism.
Tablet : 2 tablet twice daily. In severe cases, 3 times/day. DS Tablet : 1 tablet twice daily. Suspension : 1-2 teaspoonful twice daily.
Hepatic & renal insufficiency, blood dyscrasias, sulphonamides sensitivity, megaloblastic anaemia, pregnancy & during nursing.
Exfoliative dermatitis, Stevens-Johnson syndrome & toxic epidermal necrolysis (Lyell’s syndrome) are rare. Nausea & vomiting, diarrhoea, glossitis, stomatitis, anemia, granulocytopenia, purpura & agranulocytosis.
There are no controlled data in human pregnancy. -Sulfonamides may cause jaundice and hemolytic anemia in the newborn. -Sulfonamides may cause kernicterus in babies during the first month of life by displacing bilirubin from plasma albumin; therefore, they should be avoided during the last month of pregnancy. -Trimethoprim may interfere with folic acid metabolism and animal experiments have shown that administration of very high doses during organ development may cause birth defects typical of folic acid antagonism; if this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, folic acid supplementation may be required. Use is not recommended during breastfeeding.
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
.png&w=384&q=75)