For the management of Diabetes Mellitus.
Sulphonylurea; Antidlabetic
Glibenclamide appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. The mechanism by which Glibenclamide lowers blood glucose during long-term administration has not been clearly established. With chronic administration of Glibenclamide in Type 2 diabetic patients, the blood glucose lowering effect persists despite a gradual decline in the insulin secretory response to the drug. In addition to its blood glucose lowering actions, Glibenclamide produces a mild diuresis by enhancement of renal free water clearance.
Half tablet (2.5 mg) to 3 tablets. Daily doses as directed by the physician & depending on blood sugar level.
The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents, ACE inhibitors, fluoxetine, clarithromycin, and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, monoamine oxidase inhibitors, and beta adrenergic blocking agents. When such drugs are administered to a patient receiving Glibenclamide, the patient should be observed closely for hypoglycemia. When such drugs are withdrawn from a patient receiving Glibenclamide, the patient should be observed closely for loss of control. A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported. Certain drugs tend to produce hyperglycemia and may lead to loss of control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid.
Glibenclamide is contraindicated in patients with-・Known hypersensitivity to the drug or any of its excipients ・Type 1 diabetes or diabetic ketoacidosis, with or without coma This contraindicated should be treated with insulin.
Nausea, vomiting, epigastric pain, dizziness, weakness, paraesthesia & headache. Allergic skin reactions & haemopoietic reactions (leukopenia, thrombocytopenia, etc.).
There is no information on the use of glibenclamide in human pregnancy.
Store below 30°C, protected from light and moisture. Keep all medicines out of reach of children.
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