It Is IndIcated for SymptomatIc relIef of allergIc rhInItIs Upper respIratory tract dIsorders accompanIed by non-productIve cough whIch benefIts from the admInIstratIon of a nasal decongestant, a hIstamIne H1 receptor antagonIst and an antItussIve combInatIon.
This preparation is a mixture of antitussive, decongestant and antihistamine agent. Dextromethorphan is a safe, effective, non-narcotic antitussive agent which has a central action on the cough centre in the medulla. Although structurally related to Morphine, it has no analgesic and habit forming properties and in general it has little sedative activity. Phenylephrine is a decongestant that shrinks blood vessels in the nasal passage. Phenylephrine is used for the temporary relief of stuffy nose, sinus, and ear symptoms caused by the common cold, flu, allergies, sinusitis & bronchitis. This medication works by decreasing swelling in the nose and ears, thereby lessening discomfort and making it easier to breathe. Triprolidine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, watery eyes, itchy eyes/nose/throat/skin, cough, runny nose, and sneezing. It is a potent competitive histamine H1-receptor antagonist of the pyrrolidine class with mild central nervous system depressant properties which may cause drowsiness. By antagonizing another natural substance acetylcholine, it helps dry up some body fluids to relieve symptoms such as watery eyes and runny nose.
Dosage and administration Adult and children over 12 years Children of 6-12 year s 10ml or 2 teaspoonful 3 times daily Children of 2-5 years 5ml or 1 teaspoonful 3 times daily Children below 2 years 2.5ml or ? teaspoonful 3 times daily
Taking certain MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking isocarboxazid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, or tranylcypromine during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication.
It is contraindicated in patients with a known hypersensitivity to Dextromethorphan, Psedoephedrine or Triprolidine severe hypertension or severe coronary artery disease. Contraindicated in persons under treatment with MAO inhibitors within 2 weeks.
dizziness and GI disturbance. Side effects of Pseudoephedrine include symptomatic hyperactivity such as fear, anxiety, restlessness, tremor, confusion and irritability
There are no specific data on use of this combination during pregnancy. Caution should therefore be exercised by balancing the potential benefits of treatment of the mother against any possible hazards to the developing fetus.
In cases of over dosage, hospital admission is strongly advised. Over dosage may produce respiratory depression, paranoid psychosis, delusions, hallucinations and convulsion.
Store in a cool and dry place (below 30°C temperature), away from light. Keep out of the reach of children.
Each 5 ml syrup contains-
Dextromethorphan Hydrobromide BP 20 mg
Phenylephrine Hydrochloride BP 10 mg
Triprolidine Hydrochloride BP 2.5 mg
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