Dexlansoprazole is indicated for- ? Healing of Erosive Esophagitis (EE). ? Maintenance of Healed Erosive Esophagitis. ? Symptomatic Non-Erosive Gastroesophageal Reflux Disease (GERD).
Dexlansoprazole delayed-release capsule is a Proton Pump Inhibitor (PPI) which suppresses gastric acid secretion by specific inhibition of the (H+/K+)-ATPase in the gastric parietal cell. By acting specifically on the proton pump, Dexlansoprazole blocks the final step of acid production. It is the R-enantiomer of lansoprazole (A racemic mixture of the R- and S-enantiomers). Dexlansoprazole is supplied as a Dual Delayed Release (DDR) formulation in a capsule for oral administration. This capsule contains a mixture of two types of enteric coated granules with different pH-dependent dissolution profiles. The dual delayed release formulation in dexlansoprazole, plasma concentration-time profile with two distinct peaks; the first peak occurs 1 to 2 hours after administration, followed by a second peak within 4 to 5 hours. After oral administration, mean Cmax and AUC value of Dexlansoprazole increased approximately dose proportionally. Dexlansoprazole is extensively metabolized in the liver and excreated by urine.
Dosage for gastroesophageal reflux disease (GERD) Adult dosage (ages 18 years and older) Typical dosage: 30 mg taken once per day. Typical length of therapy: four weeks. Child dosage (ages 12?17 years) Typical dosage: 30 mg taken once per day. Typical length of therapy: four weeks. Child dosage (ages 0?11 years) It has not been established that this drug is safe and effective for use in children younger than 12 years. Dosage for erosive esophagitis Adult dosage (ages 18 years and older) Typical dosage: For treatment: 60 mg taken once per day. For prevention (maintenance): 30 mg taken once per day. Typical length of therapy: Up to eight weeks for treatment. For maintenance therapy, studies did not extend treatment beyond six months. Your doctor can tell you more. Child dosage (ages 12?17 years) Typical dosage: For treatment: 60 mg taken once per day. For prevention (maintenance): 30 mg taken once per day. Typical length of therapy: Up to eight weeks for treatment. For maintenance therapy, studies did not extend treatment beyond 16 weeks. Your child$#$#$#$s doctor can tell you more. Child dosage (ages 0?11 years) It has not been established that this drug is safe and effective for use in children younger than 12 years.
With medicine: Atazanavir, Warfarin, Tacrolimus, Clopidogrel & Methotrexate. With food & others: No data available.
Dexlansoprazole is contraindicated in patients with known hypersensitivity to any component of the formulation. Gastric malignancy, Clostridium difficile associated diarrhoea, bone fracture, hypomagnesemia, concomitant use of Dexlansoprazole with Methotrexate.
Common side effects include headache, nausea, vomiting, diarrhoea, abdominal pain, upper respiratory tract infection and flatulence.
Use in pregnancy and lactation : Pregnancy Category B. There are no adequate and well-controlled studies in pregnant women. It is not known whether dexlansoprazole is excreted in human milk.
There have been no reports of a significant overdose of Dexlansoprazole. Multiple doses of Dexlansoprazole 120 mg and a single dose of Dexlansoprazole 300 mg did not result in death or other severe adverse events.
Store below 30°C temperature & in a dry place, protected from light. Keep all medicines out of reach of children.
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