Topical treatment of impetigo due to Staphylococcus aureus & Streptococcus pyogenes.
Mupirocin is a naturally occurring antibiotic. It is an antibacterial agent produced by fermentation using the organism Pseudomonas fluorescens. It is active against a wide range of bacteria those responsible for the majority of skin infections, e.g. Staphylococcus aureus including methicillin-resistant Staphylococcus aureus (MRSA) other staphylococci and streptococci. It is also active against certain gram-negative pathogens, like Escherichia coli and Haemophilus influenzae. Mupirocin inhibits bacterial protein synthesis by reversibly and specially binding to bacterial isoleucyl transfer-RNA synthetase. Due to this unique mode of action, Mupirocin demonstrates no in vitro cross-resistance with other classes of antimicrobial agents. Mupirocin is bactericidal at concentrations achieved by topical administration. However, the minimum bactericidal concentration (MBC) against relevant pathogens is generally eight-fold to thirty-fold higher than the minimum inhibitory concentration (MIC).
Mupirocin is a naturally occurring antibiotic. This antibacterial agent is produced by fermentation using the organism Pseudomonas fluorescens. It is active against a wide range of bacteria (e.g. Staphylococcus aureus including methicillin-resistant strains and Streptococcus pyogenes) those responsible for the majority of skin infections. It is also active against gram-negative pathogens, such as Escherichia coli and Haemophilus influenzae. Mupirocin inhibits bacterial protein synthesis by reversibly and specifically binding to bacterial isoleucyl transfer-RNA synthetase.
A small amount of ointment should be applied to the affected area three times daily. The area treated may be covered with gauze dressing if desired.
In individuals with a history of hypersensitivity to any of its components. If a reaction suggesting sensitivity or chemical irritation should occur with the use of Mupirocin Ointment, treatment should be discontinued & appropriate alternative therapy for the infection should be instituted. As with other antibacterial products, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. When used on the face care should be taken to avoid the eyes.
Burning, stinging, pain, itching , rash, nausea, erythema, dry skin, tenderness, swelling, contact dermatitis, & increased exudate.
The drug is classified as Pregnancy Category B. Thus, this drug should be used during pregnancy only if clearly needed. Caution should be exercised when it is administered to a nursing woman
There is currently limited data with overdose of Mupirocin ointment. In the event of overdose, the patient should be treated supportively with appropriate monitoring as necessary.
Keep below 25° C temperature, protected from light and moisture. Do not keep in freeze. Keep out of the reach of children.
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