It is indicated for the treatment of rheumatoid arthritis,osteoarthritis,juvenile rheumatoid arthritis,ankylosing spondylitis,tendonitis,bursitis and acute gout. lt is also indicated lor the relief of mild to moderate pain.
Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Oxaprozin, the potassium salt of oxaprozin, is a nonsteroidal anti-inflammatory drug (NSAID), which dissociates into the active moiety oxaprozin in vivo. Oxaprozin has analgesic, anti-inflammatory, and antipyretic properties.
The mechanism of action of Oxaprozin, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2).
Oxaprozin is a potent inhibitor of prostaglandin synthesis in vitro. Oxaprozin concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because oxaprozin potassium is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.
Adult: 1200 mg per day taken in single dose or two divided doses per day. The total daily dose should not exceed 1800 mg. (26 mg/kg,whichever is lower) in oral administration. Children: For iuvenile rheumatoid arthritis: The usual dose for children over 6-16 years is recommended,the dose given orally once per day based on the body weight as follows: Child’s weight Dose 22 ? 31 kg 600 mg once daily 32 ? 54 kg 900 mg once daily > 55 kg 1200 mg once daily
Increased risk of salicylate toxicity with aspirin. May increase effects of oral anticoagulants. May reduce effects of β-blockers, diuretics and other antihypertensive agents. May increase risk of methotrexate and lithium toxicity.
Oxaprozin is contraindicated in acute peptic ulcer or if there is any hypersensitivity to Oxaprozin. lt should not be given to patients in whom aspirin or other non-steroidal anti-inflammatory/ analgesic drugs induce asthma,rhinitis or urticaria.
The more frequent reactions are nausea,vomiting,abdominal discomfort and epigastric distress, skin,rashes,urticaria,tinnitus,edema,headache,insomnia,cognitive dysfunction,anemia etc,The more serious reactions like gastrointestinal bleeding,peptic ulceration,hemorrhage,perforation and colitis etc. may occur occasionally.
Teratogenic efiects of Oxaprozin showed - Pregnancy Category C in animal studies. There are no adequate or well-controlled studies in pregnant women or lactating mother. Oxaprozin should be used during pregnancy only if the potential benefits justify the potential risks to the fetus and use in nursing mother should be avoided.
Symptoms: Acute renal failure, vomiting, drowsiness, leukocytosis.
Management: Supportive and symptomatic. Multiple admin of charcoal may be required to reduce potential for delayed toxicities.
Store at 25° C. Protect from light.
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