CLOBEON

Short courses treatment of recalcitrant eczemas: Neurodermatoses, Psoriasis (excluding widespread plaque psoriasis) where secondary bacterial infection or fungal infection is present, suspected or likely to occur. Other inflammatory conditions which do not respond satisfactorily to less active steroids.

Corticosteroid Combination

Adults: Apply sparingly to the affected area once or twice daily until improvement occurs. In very resistant lesion, specially where there is hyperkeratosis, the anti-inflammatory effect of It can be enhanced (if necessary) by occluding the treatment area with polythene. Treatment should not be continued for more than 7 days without medical supervision. If a longer course is necessary, it is recommended that treatment should not be continued for more than 4 weeks without the patient$#$#$#$s condition being reviewed. Elderly: It is suitable for use in elderly. Caution should be exercised in cases where a decrease in renal function exists & significant systemic absorption of Neomycin Sulphate may occur. Children: It is suitable for use in children (2 years & over) at the same dose as adults. A possibility of increased absorption exists in very young children, thus it is not recommended for use in neonates & infants (younger than 2 years).

This medication is contraindicated in rosacea, acne vulgaris & perioral dermatitis, primary cutaneous viral infection (eg-Herpes simplex, chicken pox) & hypersensitivity to the preparation.

Prolonged use of large amount or treatment of extensive areas can result in sufficient systemic absorption to produce the features of hypercortisolism. The effect is more likely to occur in infants & children & if occlusive dressings are used. Prolonged & intensive treatment with highly active corticosteroid preparations may cause local atrophic changes in the skin such as thinning, striae, & dilatation of the superficial blood vessels, particularly when occlusive dressings are used, or when skin folds are involved. There are reports of pigmentation changes & hypertrichosis with topical steroids.

There is little information to demonstrate the possible effect of topically applied Neomycin in pregnancy & lactation. However, Neomycin present in the maternal blood can cross the placenta & may give rise to a theoretical risk of foetal toxicity, thus the use of the preparation is not recommended in pregnancy & lactation. The safety of Clobetasol Propionate has not been established in lactating mothers.