This is indicated for the topical treatment of Acne vulgaris.
Topical antibiotic & retinoid preparations
This is a combination of lincosamide antibiotic Clindamycin phosphate and retinoid Tretinoin. Clindamycin binds with the 50s ribosomal subunit of susceptible bacteria and prevents elongation of peptide chain by interfering with the peptidyl transfer, thereby suppressing bacterial protein synthesis. Clindamycin inhibits the activity of Propionibacterium acne as reduces the occurrence of acne. Tretinoin decreases the cohesiveness of follicular epithelial cells and increases the turn over thereby brings the comedones out.
Before sleep: Wash the face gently with a mild soap and water, then pat the skin dry. Apply the Gel with finger tips through the face gently. In the morning: Apply a sunscreen after the application of Gel. Do not wash your face more than 2 or 3 times a day. Apply the sunscreen cream as needed.
Concomitant use of other potentially irritating topical products (medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, products with high concentrations of alcohol, astringents, spices or lime) should be approached with caution.
While using concomitantly with Erythromycin, the activity of both Clindamycin and Erythromycin are decreased. So, Clindamycin should not be used with Erythromycin concomitantly.
While using concomitantly with neuromuscular medicine, the activity of the neuromuscular medicine is increased. So, care should be taken during these concomitant uses.
Contraindicated in patients with hypersensitivity to clindamycin or tretinoin or any of the ingredients of these medicine. Clindamycin and Tretinoin should not be applied to eyes, nose, ear, lips, cut, burn and other infections. After the application of the Gel, keep away from sunlight.
Side effects are usually rare. Possible side-effects may includes skin rash, itching, oily skin, dryness, erythema, burning, change in skin color, diarrhea, colitis, GI disturbance etc.
Use in pregnancy: There are no well-controlled trials in pregnant women treated with Clindamycin and Tretinoin gel. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Lactating mother: It is not known whether Clindamycin and/or Tretinoin are excreted in human milk. Caution should be exercised when Clindamycin and Tretinoin gel is administered to a nursing woman.
Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children.
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