Clindamycin has been shown to be Effective in the treatment of the following infections when caused by susceptible anaerobic bacteria or susceptible strains of gram positive bacteria such as streptococci, staphylococci & pneumococci: Upper respiratory tract infections, Lower respiratory tract infections, Skin & soft tissue infections, Bone & joint infections, Pelvic infections, Intra-abdominal infections, Septicemia & endocarditis, Dental infections. As an alternative therapy when used in combination with quinine or amodiaquine for the treatment of multi-drug resistant Plasmodium falciporum infection.
Clindamycin is a lincosamide antibiotic used in the treatment of infections caused by susceptible microorganisms. Clindamycin is a semisynthetic antibiotic derived from lincomycin.
Aerobic gram-positive cocci, including: Staphylococcus aureus, Staphylococcus epidermidis (penicillinase and non-penicillinase producing strains), Streptococci, Pneumococci.
Anaerobic gram-negative bacilli, including: Bacteroides species, Fusobacterium species.
Anaerobic gram-positive non-spore forming bacilli, including: Propionibacterium species, Eubacterium species, Actinomyces species.
Anaerobic and microaerophilic gram-positive cocci, including: Peptococcus species, Peptostreptococcus species, Microaerophilic streptococci, C. perferinges
Adults: Serious Infections: 150 mg - 300 mg every six hours. More severe infections: 300 mg - 450 mg every six hours. Pediatric Patients: Serious Infections: 8 - 16 mg/kg/day divided into three or four equal doses. More severe infections: 16 - 20 mg/kg/day divided into three or four equal doses.
Clindamycin enhances the action of other neuromuscular blocking agents. Therefore, it should be used with caution in patients receiving such agents. Antagonism has been demonstrated between clindamycin and erythromycin in vitro. Because of possible clinical significance, these two drugs should not be administered concurrently.
Clindamycin is contraindicated in patients previously found to be sensitive to Clindamycin or lincomycin or any of the ingredients of this medicine.
The adverse effects have been reported with the use of Clindamycin are abdominal pain, oesophagitis & oesophagial ulcer, nausea, vomiting & diarrhoea, pruritus, skin rashes, urticaria.
Pregnancy: Pregnancy Category B: Clindamycin should be used in pregnancy only if clearly needed. Lactation : Clindamycin has been reported to appear in breast milk. Therefore, it is not recommended for nursing mothers if not clearly needed.
Overdosage with orally administered clindamycin has been rare. Adverse reactions similar to those seen with normal doses can be expected, however, unexpected reactions could occur. Haemodialysis and peritoneal dialysis are not effective in removing clindamycin from the serum. Overdosage should be treated with simple gastric lavage. No specific antidote is known.
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
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