Butamirate Citrate is used to relieve dry (non-productive) cough. Dry cough may be caused by a recent viral infection. It is also used for pre- & post-operative cough sedation in patients who will undergo surgical procedures and bronchoscopy. It can be used in acute cough of any etiology, whooping cough and cough due to acute lower respiratory tract infections (tracheitis, laryngitis, bronchitis) etc.
Butamirate Citrate acts directly on the brain's cough center to suppress cough. Butamirate Citrate is safe and non-sedating which is neither chemically nor pharmacologically related to opium alkaloids. Butamirate Citrate is rapidly and completely absorbed after oral administration. Maximum concentration is reached within 9 hours with the sustained-release tablet. This is extremely protein-bound and plasma elimination half-life is about 13 hours. The active metabolites of Butamirate Citrate have also antitussive action.
Tablet: Adult: 2-3 tablets daily at 8 to 12 hours intervals, Adolescents over 12 years old: 1-2 tablets daily. Syrup: Children (3-6 years): 5 ml 3 times daily, Children (6-12 years): 10 ml 3 times daily, Adolescent: 15 ml 3 times daily, Adult: 15 ml 4 times daily. Pediatric Drops: Children (1-3 years): 0.75 ml 4 times daily, Children (2 months-1 year): 0.50 ml 4 times daily.
Concomitant use with expectorants should be avoided.
Butamirate Citrate is contraindicated in patients with known hypersensitivity to any component of the formulation. Avoid simultanous administration of expectorants. Minor influence on the ability to drive & use machines. Avoid during pregnancy (1st 3 months) & lactation. Tablet: Rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Syrup: Sorbitol: Rare hereditary problems of fructose intolerance. Contains ethanol.
Tolerance of Butamirate Citrate is good. Adverse reactions such as rash, nausea and vertigo have been observed in a few rare cases, resolving after dose reduction or treatment withdrawal.
Butamirate Citrate should not be used during the first trimester of pregnancy. During the remainder of pregnancy, it can be used if indicated by a physician but with caution. As a general rule, for safety reasons, in the absence of data on elimination of the active substance in breast milk, the benefits of Butamirate Citrate administration during breast feeding should be carefully weighed against the risks.
Accidental overdose with Butamirate Citrate can cause the following symptoms: drowsiness, nausea, vomiting, diarrhoea, loss of balance and hypotension. Standard emergency procedures should be followed: activated charcoal, saline laxatives and standard cardio-respiratory resuscitation.
Keep away from light and moisture, store below 30°C. Keep all the medicines out of the reach of children.
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