Levamisole is a medication used to treat parasitic worm infections. Specifically it is used for ascariasis and hookworm infections.
Levamisole is the active laevo-isomer of tetramisole. It works by paralysing susceptible intestinal worms which are then excreted from the intestines. Levamisole also enhances cellular immune responses in humans.
Adult : PO Ascariasis 150 mg as a single dose. Ancylostomiasis; Mixed-ascariasis hookworm infections 2.5 mg/kg as a single dose, repeat after 7 days for severe cases. Should be taken with food. Take w/ meals to minimise side effects eg nausea.
May increase toxicity of phenytoin. Increases bioavailability of ivermectin; decreases bioavailability of albendazole. Alcohol causes disulfiram-like reaction.
Preexisting blood disorders; pregnancy and lactation; rheumatoid arthritis; severe renal impairment. Hepatic impairment, Sjogren's syndrome.
Nausea, vomiting, diarrhoea, abdominal pain, dizziness and headache. Fever, influenza-like syndrome, arthralgia, muscle pain, rash, taste disturbances and cutaneous vasculitis. Potentially Fatal: Agranulocytosis, leucopenia, thrombocytopenia.
Although studies in animals have shown that Levamisole produces no teratogenic effects, current medical practice requires that the benefits of any drug used during pregnancy should be weighed against the possible dangers.
Keep all medicines out of reach of children. Store in a cool and dry place protected from light
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