Reduce allergic reaction such as nasal congestion and urticaria
Non-sedating anti histamin(2nd genration)
Bilastine is a potent, effective, non-sedating, long-acting histamine antagonist with selective & high affinity to H1 receptor (3 times higher than Cetirizine and 5 times higher than Fexofenadine). Even at a high concentration, Bilastine does not show affinity for the 30 other receptors including muscarinic, serotonergic, dopaminergic and noradrenergic receptors, for the other histamine receptor subtypes (H2, H3 and H4). It shows excellent safety profile and very favorable pharmacokinetic characteristics. Bilastine doesn’t undergo any metabolism to be active. Bilastine is excreted by feces (non -systemic) & urine (systemic) approximately 66.35% & 28.31% respectively.
1 tablet per day for an adult person. Take the tablet on empty stomach.
Concomitant use of Bilastine with ketoconazole, erythromycin, cyclosporine or diltiazem increases the concentration of Bilastine. But these changes do not appear to affect the safety profile of any of the drugs. Intake of alcohol and 20 mg Bilastine shows same psychomotor performance similar to that of alcohol and placebo. Concomitant intake of Bilastine 20 mg and lorazepam 3 mg for 8 days did not potentiate the depressant CNS effects of lorazepam.
In clinical trials, after administration of Bilastine at doses 10 to 11 times the therapeutic dose (220 mg as single dose; or 200 mg/day for 7 days) frequency of treatment-emergent adverse events was two times higher than with placebo. The adverse reactions most frequently reported were dizziness, headache and nausea. No serious adverse events and no significant prolongation in the QTc interval were reported.
Keep below 30°C temperature, protected from light and moisture. Keep out of reach of children.
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