It has been demonstrated that inhaled beclomethasone has a beneficial effect on bronchial asthma: it improves lung function and reduces the symptoms as well as the need for oral steroids and bronchodilators.
Following topical administration into the nasal mucosa, Beclomethasone Dipropionate produces anti-inflammatory and vasoconstrictor effects. The exact mechanism of these actions remain unknown, but may involve reductions in the following: number of mediator cells (basophil, leukocytes and mast cells) at the epithelial level, number of eosinophils, sensitivity of sensory nerves to mechanical stimuli, secretory response to cholinergic receptor stimulation, and fibroblast activity. Other mechanisms may involve inhibition of capillary dilation and permeability, stabilization of lysosomal membranes and subsequent prevention of release of proteolytic enzymes.
INHALATION Asthma prophylaxis: Adult: Initially, 600- 800 mcg daily. Maintenance: 400 mcg daily in 2-4 divided doses. Child: As dipropionate: 50 or 100 mcg bid-qid or 100 or200mcg bid. Severe asthma: Adult: 250 mcg qid or 500 mcg bid. May be increased to 500 mcg 3-4 times daily it necessary. Max: 2 mg daily.
Hypersensitivity. Acute infections uncontrolled by antimicrobial chemotherapy. Active or doubtfully quiescent tuberculosis, paradoxical bronchospasm; children, elderly; pregnancy & lactation.
Loss of skin collagen & SC atrophy; local hypopigmentation of deeply pigmented skin; dryness, irritation, epistaxis, rarely ulceration or perforation of the nasal septum; smell & taste disturbances: hoarseness & candidiasis of the mouth or throat.
Benefit should outweigh risk for pregnancy. Most experts consider inhaled corticosteroids acceptable during breastfeeding as the presence in breastmilk is expected to be low and infant exposure negligible. No studies have specifically described the presence of this drug in animal milk or breast milk; however, it is reasonable to assume it is excreted in milk. Due to lack of specific data, benefits to the mother should be weighed against any potential risk to the breastfed infant.
Inhalation of excessive doses over a short time period may suppress hypothalamic pituitary adrenal (HPA) function, and no special emergency action need to be taken, rather treatment should be continued at recommended dose. HPA function recovers within one or two day
Store at a temperature not exceeding 30°C. Protect from light & moisture. Keep out of the reach of children.
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