Cefuroxime Axetil & Clavulanic Acid combination is indicated in- Pharyngitis and/or tonsillitis Acute bacterial otitis media Acute bacterial maxillary sinusitis Lower respiratory tract infections including pneumonia Acute bacterial exacerbations of chronic bronchitis and secondary bacterial infections of acute bronchitis Skin and Skin-Structure Infections Urinary tract infections Bone and Joint infections Gonorrhea: Uncomplicated and disseminated gonococcal infections Early Lyme disease (erythema migrans) Septicemia Meningitis Switch therapy (injectable to oral) after surgery when patient’s condition is improved.
2nd Generation Cephalosporin; Antimicrobial
Cefuroxime is a bactericidal second generation cephalosporin antibiotic which is active against a wide range of Gram-positive and Gram-negative susceptible organisms including many beta-lactamase producing strains. Cefuroxime inhibits bacterial cell wall synthesis by interfering with the transpeptidation process.
Clavulanic acid is a naturally derived beta lactamase inhibitor produced by Streptomyces clavuligerus. It has similar structure to beta lactam antibiotics which binds irreversibly to beta-lactamase enzymes and inactivates them. Clavulanic acid gives protection of Cefuroxime from degradation by beta lactamase enzymes and provides a solution for the treatment of bacterial infections caused by beta lactam resistant bacteria.
Pharyngitis or Tonsillitis: 250 mg twice daily for 5-10 days Acute bacterial maxillary sinusitis: 250 mg twice daily for 10 days Acute bacterial exacerbation of chronic bronchitis: 250-500 mg twice daily for 10 days Secondary bacterial infections of acute bronchitis: 250-500 mg twice daily for 5-10 days Community acquired pneumonia: 250-500 mg twice daily for 5-10 days Uncomplicated skin & skin-structure infections: 250-500 mg twice daily for 10 days Multidrug resistant typhoid fever: 500 mg twice daily for 10-14 days Uncomplicated urinary tract infection: 250 mg twice daily for 7-10 days Uncomplicated gonorrhea: 1000 mg once single dose Lyme disease: 500 mg twice daily for 20 days Cefuroxime & Clavulanic Acid may be administered without regard to meals.
Concomitant administration of probenecid with Cefuroxime-Clavulanic Acid increases the area under the serum concentration versus time curve by 50%. Drug that reduces gastric acidity may result in a lower bioavailability of Cefuroxime and tend to cancel the effect of postprandial absorption.
It is contraindicated in patients with known allergy to Cefuroxime and Clavulanic acid or to the cephalosporin group of antibiotics. Cefuroxime should be given with caution to patients receiving concurrent treatment with potent diuretics because these diuretics are suspected of adversely affecting renal function. Cefuroxime, as with other broad-spectrum antibiotics, should be prescribed with caution in individuals with a history of colitis.
Generally Cefuroxime and Clavulanic acid are well tolerated. However, a few side effects like nausea, vomiting, diarrhea, abdominal discomfort or pain may occur.
Both Cefuroxime and Clavulanic acid are pregnancy category B. Cefuroxime is excreted in human milk; consideration should be given to discontinuing nursing temporarily during treatment with Cefuroxime.
Store in a cool, dry place (below 30o C), away from light and moisture. Keep out of the reach of children.
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