Pharyngitis, sinusitis, otitis media, tonsilitis, laryngotracheo-bronchitis, acute & chronic bronchitis, lobar & bronchopneumonia, cystitis,urethritis, pyelonephritis, abscess, cellulitis,furunculosis, impetigo, bacillary dysentery, enteritis, peritonitis. bone & joint infection, surgical prophylaxis.
1st Generation Cephalosporin; Antimicrobial
Cephradine is a semisynthetic broad spectrum bactericidal antibiotic, it is active against infections caused by both gram-positive and gram-negative microorganisms. Both penicillinase producing and nonproducing staphylococci are sensitive to Cephradine. The main site of action of Cephradine is the cell wall of bacteria. Cell wall of sensitive organism contains peptidoglycan. Cephradine inhibits cross-linking process and as a result cell wall with many pores are formed, thus lysis of bacteria occur due to external osmotic pressure.
1-2 gm daily in 2 to 4 divided doses.
The concomitant use of nephrotoxic drugs such as aminoglycosides with Cefradine may increase the risk of kidney damage. Diuretics (e.g. frusemide, ethacrynic acid) and probenecid enhanced the possibility of renal toxicity.
Hypersensitivity to any Cephalosporin antibiotic.
Nausea, vomiting, diarrhoea & abdominal discomfort, allergic reactions, skin rashes, urticaria, eosinophilia, angioedema & anaphylaxis, elevation of hepatic enzyme values, neutropenia, Super-infection with resistant microorganisms, particularly candida, pseudomembranous colitis. Thrombophlebitis.
The drug should be used during pregnancy only when clearly indicated, the drug should be used with caution in nursing mother.
The symptoms of Sefrad overdose are non-specific and are generally nausea, vomiting, diarrhoea and gastric upsets. Treatment is mainly supportive although gastric lavage will be necessary if a large amount has been ingested.
Cephradine Suspension should be freshly prepared. Reconstituted Suspension should be used within 7 days if kept at room temperature or within 14 days, if kept in a refrigerator. Cephradine Injection solutions should be used within 2 hours when kept at room temperature. When stored at 5°C, solutions retain potency for 12 hours. Reconstituted solutions may vary in colour from light to straw yellow; however, this does not affect the potency. Do not use later than the date of expiry. Keep all medicines out of the reach of children. To be dispensed only on the prescription of a registered physician
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