Acute Cerebro-Vascular Accidents (Stroke): Ischemic stroke due to cerebral thrombosis, cerebral embolism, acute circulatory disorder, hypertensive crisis; the acute cardiovascular disorders, reversible ischemic neurological deficit (RIND), complete stroke (CS), multiinfarct dementia, cerebral arteriosclerosis, hypertensive encephalopathy, postapoplectic conditions with the background of hemorrhagic strokes etc. Geriatrics: For relief of psychosomatic symptoms in the elderly due to cerebral insufficiency e.g. forgetfulness, memory disturbances, slow thinking, lack of concentration, dizziness, mood instability, aphasia, sleep disturbances, vasovegetative symptoms of menopausal syndrome etc. Ophthalmology: Vascular disorder of the choroid & retina due to arteriosclerosis. Vasospasm, macula degenerations, arterial or venous thrombosis or embolism or glaucoma secondary to above mentioned disorders. Otology: For the treatment of impaired hearing of vascular toxic (iatrogenic) origin presbyacusis. Meniere’s disease, cochleovestibular neuritis, tinnitus & dizziness of labyrinth origin.
Vinpocetine increases cerebral metabolism; it increases glucose and O2 consumption; improves cerebral hypoxia tolerance; shifts glucose metabolism to the energetically more favourable aerobic pathway, but it increases the anaerobic pathway as well; it elevates the ATP concentration and the ATP/AMP ratio in the brain, and elevates the cerebral norepinephrine, dopamine and serotonin levels.
Vinpocetine considerably improves cerebral microcirculation by inhibiting platelet aggregation, reducing the pathologically increased blood viscosity, and increases erythrocyte deformability. It also promotes O2 transport into the tissues by reducing the O2 affinity of erythrocytes.
It selectively and intensely increases cerebral blood flow and the share of the brain in cardiac output, it reduces cerebral vascular resistance without affecting systemic circulation (blood pressure, heart rate, cardiac output, total peripheral resistance). It does not elicit steal phenomenon; on the contrary, it primarily improves the blood supply of the injured and ischaemic area while it remains unchanged in the intact areas (inverse steal effect). It further increases blood flow which is already increased as a result of hypoxia.
1-2 tablets thrice daily, the maintenance dose is one tablet thrice daily.
The injection is chemically incompatible with heparin, therefore, it should not be injected in the same syringe.
Contraindicated to pregnant & breastfeeding women. Caution should be exercised in patients with history of high blood pressure & heart disease.
Transient hypotension, tachycardia may occur.
Avoid use during pregnancy and lactation because of lack of clinical studies.
Store in a cool and dry place, protected from light and moisture.
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