? Upper respiratory tract infections caused by Streptococcus pyogenes (Group A betahemolytic Streptococci) & Streptococcus pneumoniae. ? Urinary tract infections caused by E. coli, Proteus mirabilis, & Klebsiella species. ? Skin & soft tissue infections caused by Staphylococci (including penicillinase producing strains) & Streptococci.
1st Generation Cephalosporin; Antimicrobial
Cefadroxil inhibits bacterial cell wall synthesis by binding to 1 or more of the penicillin-binding proteins (PBPs) which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Dosage & Administration Infections of upper respiratory tract:Adult - pharyngitis & tonsillitis: 1 g/day in single or divided doses for 10 days, Children- 30 mg/kg/ day in equally divided doses every 12 hour for at least 10 days. Uncomplicated lower urinary tract infections: Adult- 1-2 g daily as a single or2 divided doses, Children- >6 year: 500 mg bid; 1-6 year: 250 mg bid; <1 year: 25 mg/kg daily in divided doses. Skin & soft tissue infections: Adult- 1 g/day in single or divided doses, Children- 30 mg/kg/day in equally divided doses every 12 hour
Prothrombin time will be prolonged; bleeding may occur when taken with anticoagulants. Decreased elimination with Probenecid is also reported.
Cefadroxil is contraindicated in patients with a history of hypersensitivity to any of the ingredients Cefadroxil should be used with caution in the presence of markedly impaired renal function (creatinine clearance rate of less than 50 ml/ min). For patients considering creatinine clearance of ml/min/1.73 sqm, starting dose 1000 mg & maintenance dose 500 mg should be administered as per following table: Creatinine clearance Dosing interval (ml/min) 1-10 36 hr. 11-25 24 hr. 26-50 12 hr. >50 No need to adjust Cefadroxil can be excreted from body by hemodialysis. Prolonged use of Cefadroxil may result in the overgrowth of nonsusceptible organisms. Cefadroxil should be prescribed with caution in individuals with history of gastrointestinal disease, particularly colitis.
The most commonly reported side effects are ,gastrointestinal disturbances & hypersensitivity phenomena. Side effects including nausea, vomiting, diarrhoea, dyspepsia, abdominal discomfort, fever, dizziness, headache, arthralgia may also occur.
Pregnancy category B. But it should be used only if clearly needed. Caution should be exercised when Cefadroxil is administered to nursing mother.
No clinical reports are as yet available on cefadroxil in this respect. However in view of experience gained with other cephalosporins the following symptoms are possible: nausea, hallucinations, hyperreflexia, extrapyramidal symptoms, clouded consciousness, or even coma and renal functional impairment.
Keep in a dry place away from light and heat. Keep out of the reach of children.
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