Anxiety along with depression.
This consists of two well known and well proven compounds: flupentixol-a neuroleptic with anxiolytic and antidepressant properties of its own when given in small doses, and melitracen-a bipolar thymoleptic with activating properties in low doses. In combination the compounds render a preparation with antidepressant, anxiolytic and activating properties. Maximal serum concentration is reached in about 4 hours after oral administration of flupentixol and in about 4 hours after oral administration of melitracen. The biological half-life of flupentixol is about 35 hours and that of melitracen is about 19 hours. The combination of flupentixol and melitracen does not seem to influence the pharmacokinetic properties of the individual compounds.
2 tablets in a day, 1 in morning & another at mid day.
This tablet may enhance the response to alcohol, barbiturates and other CNS depressants. Simultaneous administration of MAO-inhibitors may cause hypertensive crises. Neuroleptics and thymoleptics reduce the antihypertensive effect of guanethidine and similar acting compounds and thymoleptics enhance the effects of adrenaline and noradrenaline.
Hypersensitivity to Melitracen & Flupenthixol, depression of the CNS (e.g. at the time of acute intoxications to alcohol, barbiturates or opiates), state of coma, pheochromocytoma, blood dyscrasy, immediately consecutive recovery to a myocardial infarction, at the time of a cardiac block of any rank, disorders of cardiac conduction as well as coronary insufficiency. The concomitant administration of inhibitors of the MAOIs are contra-indicated. The administration of this requires prudence among patients presenting an organic cerebral lesion, convulsions, urinary retention, hyperthyroid, parkinson’s syndrome, serious myasthenia, advanced hepatic affection as well as cardiovascular disorders. Among depressive patients, the risk of suicide remains during the treatment. As for all nerve sedatives, a syndrome nerve sedative (potentially fatal) can seldom occur. Extrapyramidal disorders can occur in very rare cases.
Side Effects are rare. These could be transient restlessness & insomnia.
Flupentixol-melitracen combination should preferably not be given during pregnancy and lactation.
In cases of overdosage the symptoms of intoxications by melitracen, especially of anticholinergic nature, dominate. More rarely extrapyramidal symptoms due to flupentixol occur. Symptomatic and Supportive. Gastric lavage should be carried out as soon as possible and activated charcoal may be administered. Measures aimed at supporting the respiratory and cardiovascular systems should be instituted. Epinephrine (adrenaline) must not be used for such patients. Convulsions may be treated with diazepam and extrapyramidal symptoms with biperiden.
Store at a temperature not exceeding 30°C in a dry place. Protect from light. Keep out of reach of children.
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