Post-operative pain, colic & spastic pain, cancer pain, joint pain, neck & back pain, pain associated with osteoporosis.
Tramadol is a centrally acting synthetic analgesic compound. It inhibits the re uptake of neurotransmitters- serotonin and noradrenaline. Thus it modifies the transmission of pain impulses by activating both descending serotonergic pathways and noradrenergic pathways involved in analgesia. The analgesic effects of Tramadol are mediated via stimulation of mu-opioid receptors and indirect modulation of central monoaminergic inhibitory pathways.
Usual doses are 50-100 mg every four to six hours. For acute pain an initial dose of 100 mg is required.
In general, physician need not be concerned about drugs interacting with Tramadol. The monoamine oxidase (MAO) inhibitors represent the only drug class not recommended for combination with Tramadol. Concomitant administration of carbamazepine with Tramadol causes a significant increase in Tramadol metabolism and it requires to increase the dose of Tramadol.
Hypersensitivity, acute intoxication with alcohol, hypnotics, centrally acting analgesics, opioids or psychotropic drugs. Tramadol should be used with caution in patients with increased intracranial pressure or head injury & patients with acute abdominal conditions.
Dizziness/vertigo, nausea, constipation, headache, somnolence, vomiting, pruritus, CNS stimulation, asthenia.
Tramadol should be used during pregnancy only if the potential benefit justifies the risk to the fetus.
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
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