Used to prevent and treat nausea, vomiting, and dizziness caused by motion sickness. It may also be used to reduce dizziness and loss of balance (vertigo) caused by inner ear problems.
Piperazine Derivative; Antiemetic/Antivertigo
Meclizine has antiemetic, anticholinergic and antihistaminic properties. It reduces the sensitivity of the labyrinthine apparatus. The action may be mediated through nerve pathways to the vomiting center (VC) from the chemoreceptor trigger zone (CTZ), peripheral nerve pathways, the VC, or other CNS centers. Meclizine has an onset of action of 30 to 60 minutes, depending on dosage; their duration of action is 12 to 24 hours.
ORAL Motion sickness: Adult: 25-50 mg 1 hr before travelling & repeat every 24 hr If needed. Child: As hydrochloride: 2-6 yr: 6.25 mg once daily; 6-12 yr: 12.5 mg once daily; >12 yr: 25-50 mg 1 hr before travelling & repeat every 24 hr if needed. Vertigo & vestibular disorders: Adult: Up to 100 mg daily in divided doses.
Additive CNS depression may occur where meclizine hydrochloride are administered concomitantly with other CNS depressants including barbiturates, tranquilizers and alcohol.
Angle-closure glaucoma, prostatic hyperplasia; pyionc or duodenal obstruction; asthma. Elderly. May affect the ability to drive or operate machinery. Pregnancy & lactation.
Drowsiness, thickening of bronchial secretions, dry mouth, fatigue, blurred vision.
Animal studies have shown cleft palates at 25 to 50 times the human dose. However, epidemiological studies in pregnant women do not indicate this drug increases the risk of abnormalities when administered during pregnancy. Occasional doses of meclizine are probably acceptable during breastfeeding. Large doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established.
Store in a cool & dry place and away from children.
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