Children: - Reduced or absence of pancreatic exocrine secretion -Cystic fibrosis Adults: In the conditions with deficient pancreatic exocrine function such as -Following pancreatectomy -Following total gastrectomy -Chronic pancreatitis -Steatorrhea -Somatostatinoma -Celiac disease
Pancreatin is a preparation of Pancreatin, an extract from mammalian pancreas containing enzymes with Amylase, Protease and Lipase activity. It is designed to disintegrate in the alkaline medium of the duodenum where it releases the active enzyme components of Pancreatin (Amylase, Protease and Lipase). Amylase hydrolyzes dietary starch to yield maltose, maltoriose and a-dextrin. Protease cleaves peptide bonds in the center of proteins and polypeptides and forms amino acids and oligopeptides. Lipase hydrolyzes dietary triglycerides forming two molecules of fatty acid and a molecule of beta-monoglyceride. It converts not less than 25 times its weight of starch into soluble carbohydrates and not less than 25 times its weight of casein into proteoses within 5 mins, (equivalent to 150 times in 30 mins).
1-3 tablets daily with meal or as per direction of the physician.
Alkaline media will rupture the enteric coating. As such to prevent bursting out of the content in the stomach Pancreatin should not be used concurrently with antacid.
A proper balance between fat, protein & starch intake must be maintained to avoid temporary indigestion.
Pancreatin may cause buccal & perianal soreness, particularly in infants. Hypersensitivity reactions have been reported; these may be sneezing, lacrimation or skin rashes.
Pregnancy category C. Not known whether Pancreatin is distributed into milk. Caution advised if Pancreatin is used.
Excessive dosage may produce a laxative effect. Systemic toxicity does not occur. Very high dosage may cause hyperuricaemia and hyperuricosuria
Keep all medicines out of reach of children. Store in a cool and dry place, protected from light.
Each enteric film-coated tablet contains 325 mg of Pancreatin BP that provides not less than the following enzymatic activity-
Amylase 7800 units
Protease 455 units
Lipase 6500 units
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