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Calcium and Vitamin D3 is used for the treatment of Osteoporosis, Osteomalacia, Rickets, Tetany, Parathyroid disease etc.
Algae source Calcium is a plant based Algae which is hand harvested, sun dried,
then milled into a powder. The Algae plant draws Calcium and 12 other essential
bone supporting minerals from seawater.
The pharmacokinetic profiles of Calcium and its salts are well known. Calcium
carbonate is converted to calcium chloride by gastric acid. Calcium is absorbed to
the extent of about 15-25% from the gastro-intestinal tract while the remainder
reverts to insoluble calcium carbonate and calcium stearate, and is excreted in the
feces.
The pharmacokinetics of vitamin D3 is also well known. Vitamin D3 is well absorbed
from the gastro-intestinal tract in the presence of bile. It is hydroxylated in the
liver to form 25-hydroxycholecalciferol and then undergoes further hydroxylation in
the kidney to form the active metabolite 1, 25 dihydroxycholecalciferol (calcitriol).
The metabolites circulate in the blood bound to a specific α-globin. Vitamin D and
its metabolites are excreted mainly in the bile and feces.
One tablet in the morning and one tablet at night or as directed by the Physician.
It has possible interaction with digoxin, antacids containing Calcium, Aluminum or Magnesium, other Calcium supplements, Calcitriol, Tetracycline, Doxycycline, Aminocycline or Oxytetracycline etc.
Absolute contra-indications are hypercalcemia resulting for example from
myeloma, bone metastases or other malignant bone disease, sarcoidosis, primary
hyperparathyroidism and vitamin D3 over dosage. Severe renal failure. Hypersensitivity
to any of the tablet ingredients. Relative contra-indications are osteoporosis
due to prolonged immobilization, renal stones, and severe hypercalciuria.
Orally administered Calcium Carbonate may be irritating to the GI tract. It may also
cause constipation. Hypercalcemia is rarely produced by administration of Calcium
alone, but may occur when large doses are given to patients with chronic renal
failure. Also there may be allergic reactions, irregular heartbeats, nausea,
vomiting, decreased appetite dry mouth and drowsiness. Following administration
of Vitamin D3 Supplements occasion skin rash has been reported.
It should be used as directed by the physician during Pregnancy and Lactation.
Store at a cool and dry place below 300 C protected from light and moisture. Keep out of the reach of children.
Calcium Carbonate USP 1250 mg (from Algae source)
equivalent to 500 mg of elemental Calcium and Cholecalciferol USP 5 mcg equivalent to Vitamin D3 200 IU